572 search results for “lysosomal strong disorder” in the Public website
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Extremely shy and genetically close
Investigating neurobiological endophenotypes of Social Anxiety Disorder
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Yvette Dijkxhoorn
Faculty of Social and Behavioural Sciences
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Julie HallFaculty of Social and Behavioural Sciences
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Hans Aerts -
The recognition process of youth with problematic anxiety in general practice
Do general practitioners recognize children with or at risk of problematic anxiety and is there a pattern that might help differentiate those with and without anxiety disorders in general practice?
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Better screening can help GPs recognise anxiety disorders earlier
Only one in five young people with emotional health problems such as an anxiety disorder receives appropriate professional help. GPs often fail to properly recognise the signals in children and young people, according to psychologist Semiha Aydin. How can we improve this? PhD defence 23 February.
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How brain disorder models are like the Night Watch
Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.
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Emotion regulation in young children with autism
Children with autism spectrum disorder experience serious challenges in social functioning, which threatens their development in many areas of functioning.
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Andrea SpruijtFaculty of Social and Behavioural Sciences
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More research needed into the pill and mood disorders
The use of the pill, in combination with genetic factors, can influence experimental psychological research in women. More research is needed into the influence of the pill on mood disorders, concludes psychologist Daniëlle Hamstra. PhD defence on 30 September.
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Eiko FriedFaculty of Social and Behavioural Sciences
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Evelien UrbanusFaculty of Social and Behavioural Sciences
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Rianne de KleineFaculty of Social and Behavioural Sciences
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Maartje SchoorlFaculty of Social and Behavioural Sciences
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Marike KooistraFaculty of Social and Behavioural Sciences
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Leo de Sonneville
Faculty of Social and Behavioural Sciences
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Nikki NibberingFaculty of Social and Behavioural Sciences
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Born to be shy?
An international mega-analysis on the neurobiological link between inhibited temperament and social anxiety disorder
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Elise KortinkFaculty of Social and Behavioural Sciences
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Janna Marie Bas-HoogendamFaculty of Social and Behavioural Sciences
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'Personalized medicine' as ideal in treatment of psychiatric disorders
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Biorythm and brain dysfunction
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Blog Post | From ‘Disinformation’ to ‘Information Disorder’: Changing the Narrative about Unwanted Communication
Disinformation has become a popular subject of study and debate. A plethora of publications and policies have emerged, aiming to analyse and curb the negative consequences of unwanted communication.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Chemical biology studies on retaining exo-β-glucosidases
The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).
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Frederiek Halbertsma
Faculty of Social and Behavioural Sciences
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Johanna Greeven
Faculty of Social and Behavioural Sciences
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Thomas WillemsFaculty of Social and Behavioural Sciences
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Replacing fear with something new: Using novelty to unlearn fear.
This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.
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group presentation in CSM elective Governance of crime and social disorder
If you know a crime is about to occur, should you be able to prevent it before it has even happened? This was one of the questions that was posed in light of predictive policing as a form of mass surveillance during the debate in the elective Governance of Crime and Social Disorder class of the Crisis…
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Stress, hormones and emotion regulation
What is the role of stress and stress-related hormones in emotion regulation?
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Shy parent, shy child?
Delineating psychophysiological endophenotypes of social anxiety disorder
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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XXY versus autism: evidence from neuroimaging
Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI
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Danielle OprelFaculty of Social and Behavioural Sciences
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Hinke EndedijkFaculty of Social and Behavioural Sciences
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Jan Dirk BlomFaculty of Social and Behavioural Sciences
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Students win poll in CSM elective ‘governance of crime and social disorder'
Teacher Dr. Elke Devroe introduces group role-play on actual themes of governance of crime and social disorder. Seven groups of 5 students each presented last Tuesday March 17th pro’s and con’s of the topic of their choice in a panel in a TV-show setting. Students enjoyed lifting green and red cards…
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Greta NoordenbosFaculty of Social and Behavioural Sciences
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Autism and higher education
How can we improve quality of life and study success in young, high-functioning adults with autism?
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On electronic signatures of topological superconductivity
Promotor: Prof.dr. C.W.J. Beenakker
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Degradome analysis of vaccines
The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.
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Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.
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Executive deficits in relation to early reading and math development
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Semiha AydinFaculty of Social and Behavioural Sciences
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Severe behavioral and emotional problems, special education and youth care
Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.