Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.

Binnen het project eCodicesNL (Huygens ING) kunnen stagiairs aan de slag van februari tot en met mei 2022. Tegen een stagevergoeding van 250 euro per maand mag je handschriftbeschrijvingen in XML-TEI creëren, corrigeren en updaten. Ben je geïnteresseerd? Stuur dan je motivatiebrief en CV voor 11 december…

Van 4 tot en met 8 juli 2022 verzorgt Radboud Erfgoed in Nijmegen een Summer School (in het Nederlands) over erfgoedcollecties, hun geschiedenis, over sporen van gebruik en wat die ons leren over de mensen die de boeken en objecten verzamelden die nu onze collecties vormen. De deelnemers gaan aan de…

All kinds of reasons have been put forward for why plants apparently fail to make maximum use of the available light. None of these reasons can explain why after two billion years of evolution they are not black, like industrial photovoltaic solar cells. Are we missing something?

Mariëtte Huizinga, Dorien Graas and Anika Bexkens call attention to learning problems of children with mild intellectual disability in the classroom. Their new book aims to make it easier for teachers to respond to the specific educational needs of these children.

This year, the National Clean-up Day, in an adapted form, will take place. Join us and take a clean-up walk on Saturday, March 20.⠀

An important award like the Spinoza Prize, the 'Dutch Nobel Prize', generates lots of media attention. An overview.

Het project heeft plaats gevonden onder begeleiding van Prof.dr.ir.Tjerk Oosterkamp. De titel van de presentatie is:

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

There are around 300,000 people in the Netherlands who donate blood on a regular basis. Women can give blood up to three times a year and men up to five times, resulting in approximately one million blood donations each year. Patients that receive this donated blood are already in a vulnerable condition,…

We depend on nature for so many things: from clean water, wood and food to carbon absorption, water purification and coastal protection, as well as for relaxation, inspiration and identity. Nevertheless, our modern world putting increasing pressure on these ecosystem services. Leiden researchers investigate…

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

Leiden physicists have developed a way to address how accurately a superconducting single photon detector (SSPD) can be characterized by detector tomography. SSPDs are not fully understood, and tomography is a key element to determine how these devices detect light. A better understanding of these detectors…

The Plastic Soup Foundation and Parley for the Oceans hosted the very first Plastic Heath Summit in Amsterdam on 3 October, covering the most relevant and pressing health concerns surrounding plastics and human health. Beyond discussing the latest findings in the field we asked the urgent question:…

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

It is the largest database for space ice yet: The Leiden Ice Database for Astrochemistry: LIDA. Created by astrophysicists at the Leiden Observatory, LIDA includes not only hundreds of measurement data, but also software to examine astronomical observations and prepare new measurements with the James…

The Business, Technology & Public Policy research group of the Department of Business Sciences at Leiden University focuses on investigating the dynamic interaction between 'new' technologies and various stakeholders, including consumers, employees, and businesses. Our research delves into perceptions,…

The Dick Stufkens Prijs for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) has been awarded to Dr Tatu S. Kumpulainen for his thesis “Proton-Transfer Reactions in ‘Super’ Photoacids and Supramolecular Assemblies”. It describes his innovative research into methods for…

The research group Organizational & Entrepreneurial Behavior investigates the behavior of individuals and groups who start, work in, or lead organizations, in order to inform organizational practice. By focusing on the behavior of (groups of) employees, entrepreneurs and leaders, the main levels of…

Overview of the CML reports

On September 12, Michel Orrit received his Spinoza prize in the Royal Theatre in The Hague from OCW Secretary of State Sander Dekker. With the award comes a budget of 2.5 million euro, to be spent freely on scientific research, and the coveted Spinoza statue. Orrit shared the honor with Eveline Crone…

Scientists have developed a material that breaks one of the fundamental principles governing many physical systems. Ordinary materials transmit external forces equally, no matter where the pressure comes from. The newly developed material breaks this rule and could potentially be of interest in soft-robotics…

ELS@Leiden research encompasses a wide range of empirical-legal projects carried out within Leiden Law School from the perspective of multiple disciplines and methods. Here you can find the publications of our (former) lab members since the start of the Sector Plan.

Tussen de sterren is niet alleen leegte. Er zweven ook stoffen als methanol en koolstofdioxide. Chemische theorieën kunnen nog niet verklaren hoe die zijn ontstaan onder omstandigheden die dat juist onmogelijk zouden moeten maken. Fedor Goumans gaat met een Veni-beurs proberen die vraag te beantwoor…

Lecture

The Battle of Heiligerlee, on 23 May 450 years ago, is famous as an epic battle in Dutch history. But was it really so momentous? Professor of Early Modern History Judith Pollmann unravels the myths about ‘Heiligerlee’ and the Eighty Years' War.

Environmental researcher Martina Vijver is over the moon with her ERC Consolidator Grant. This prestigious grant is recognition, she says, of the study of the behaviour and possible toxicity of new nanomaterials in ecosystems.

Marie Curie once said: I have no dress except the one I wear every day. If you are going to be kind enough to give me one, please let it be practical and dark so that I can put it on afterwards to go to the laboratory.

A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.

Your local city park may be improving your health, according to a new paper led by Leiden environmental scientist Roy Remme. In Proceedings of the National Academy of Sciences Remme and his colleagues describe how access to nature increases people’s physical activity—and therefore overall health—in…

Lecture

The Dick Stufkens Prize 2020 for the best PhD thesis of the Holland Research School of Molecular Chemistry has been awarded to Dr Mark Koenis. Koenis graduated 21 February with the distinction cum laude on his thesis 'Advanced Spectra Analysis to Determine Complex Structure and Chirality'. He describes…

Sixteen researchers at Leiden University have received a Veni award from the Netherlands Organisation for Academic Research (NWO). This award offers promising young researchers the opportunity to further develop their ideas for a period of three years.

An unprecedented space telescope, an astrolab that makes space ice and molecules that may lead to the origin of life… The Ice Age project has all the prerequisites to become a very fascinating research project – if it is not one already. Leiden astronomers Melissa McClure, Harold Linnartz and Will Rocha…

The Dick Stufkens Prize 2019 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Thom Hersbach. In his thesis, Hersbach presents a thorough analysis of cathodic corrosion. His comprehensive research, on which he graduated with the distinction cum…

Lecture

Lecture

Finally we know for sure that there is a black hole at the centre of our own galaxy. Today, astronomers unveiled the first ever photo of Sagittarius A*, a super-massive object at the centre of the Milky Way. This picture could only be taken thanks to the cooperation of telescopes worldwide.

Lecture

Lecture

This year, NWO has awarded a Veni subsidy to 143 young researchers who have recently obtained their PhD. 17 of these researchers are at Leiden University and one works at the LUMC. The successful applicants will each receive 250,000 euro to develop their ideas and carry out research over a period of…