The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Eva Michaels & Monika Sus examine strategic autonomy in EU foreign policy, tracing evolution from the 1998 Saint-Malo Declaration to its current focus.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

Conference

As part of a wish fulfilment from Make-A-Wish, Leiden University recently welcomed a very special guest. Together with her best friend, Yuliia participated in a practical session on February 24th, where they studied the brain of a calf.

It is important for social animals to be able to recognise one another quickly. Humans are able to recognise each other immediately from their faces. Faces are also important for chimpanzees, but a new study by neuropsychologist Mariska Kret in PLOS ONE shows that the animals' buttocks also play a…

Members of the collective explore what it means to be ‘human’, in the past and present, from a range of different perspectives and inter-disciplinary approaches.

At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

In the spirit of 'unity in diversity', our objective is to promote insight into and appreciation for the wonder that the same physical laws and mathematical concepts apply to the whole of nature, from the largest to the smallest energy and length scales. We strive for the application of abstract theoretical…

We have recently discovered that there are biological proteins that phase separate out of solution much the way oil will de-mix from water (see movie). These form dense, liquid-like phases called protein condensates.

A study by a Leiden-Wageningen group shows that present-day humans are biologically poorly equipped to deal with the toxins they are regularly exposed to in smoky environments: compared to earlier hominins, we modern humans are probably even worse off. The study appeared in Molecular Biology and Evolution.…

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

On Friday March 12 2021.

Narrative Science examines the use of narrative in scientific research over the last two centuries.

During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Promotor: Prof.dr. E.J.J. Groenen

Find out about the effects of Brexit on contracts and supplies.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Key publications of the Biomedical Microscale Analytics group.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.