2,500 search results for “discovery of the yuan” in the Public website
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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation
Source: PLoS ONE, Volume 10, Issue 3 (2015)
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Bhattacharyya Lab - Quantum transport in 2D materials
The research group of Semonti Bhattacharyya at the Leiden Institute of Physics studies quantum transport measurements in Van der Waals heterostructures.
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Jebel Aruda: An Uruk period temple and settlement in Syria (Volume II)
Volume II: Plates of Room Contents
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MicroClock: The Bacillus subtilis circadian clock, from molecules to mutualism
The central aims of MicroClock project are to describe the B. subtilis circadian clock at molecular and functional levels, and discover the mechanisms of clock-regulated bidirectional signaling between B. subtilis and the model plant Arabidopsis
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Jebel Aruda: An Uruk period temple and settlement in Syria (Volume I)
Volume I: Excavation and Material Culture
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Biomedical Metabolomics Facility Leiden
The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Respiratory-chain enzymes
Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…
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Early death of massive galaxies in the distant universe
Promotor: M. Franx, Co-Promotor: I.F. Labbé
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Discover More HyperVelocity Stars to shed light on the Galaxy
Rossi
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Microglial lipid metabolism: a delicate balance
Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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LED3 & LUCID Drug Discovery Meeting
Conference
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Anthe JanssenFaculty of Science
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Mario van der SteltFaculty of Science
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The δ-machine: A new competitive and interpretable classifier based on dissimilarities
Does the δ-machine have higher accuracy than the other feature-based classifiers in some conditions?
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Gerrit van der KooijFaculty of Archaeology
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Astronomer Joe Callingham testifies against killer stars in new show on Discovery Channel
On Friday evening 17 September, Leiden astronomer Joe Callingham can be seen in a new series on Discovery channel. Killers of the Cosmos is about different deadly dangers lurking in the depths of space. Asteroids, cosmic debris, electromagnetic weapons… The show takes a film-noir approach to these threats,…
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Three discoveries for cleaner and cheaper fuel
How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.
- El-Hosh
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Efficient Chemistry for new antibiotics against C. difficile
How can efficient chemical synthesis and clinical microbiology be combined to identify new antibiotics against Clostridioides difficile infections?
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Awards and Grants 2026
On this page you will find an overview of awards and prizes granted to our staff and students in 2026, as well as special appointments at Leiden University and other institutions.
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Centre for the Arts in Society (LUCAS)
Leiden University Centre for the Arts in Society (LUCAS) is dedicated to ground-breaking and interdisciplinary research dealing with the relations between culture and society.
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TOWARD A CINEMA OF UN-BELONGING: RITES OF PASSAGE FOR THE DIASPORIC ERA
Could an emergent Cinema of Un-Belonging discover forms of narrative time relevant to the long-term, inter-generational fractures caused by forced traumatic dispersion?
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Metabolomics Facility
The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
- Research output
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The Dakhleh Oasis Project
Update : March 2020 A.J. Mills
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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It's about time
This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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Jorre TheFaculty of Science
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Keara TheFaculty of Social and Behavioural Sciences
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Diederik MeijerFaculty of Archaeology
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Merel BrüningFaculty of Archaeology
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Maria HadjigavrielFaculty of Archaeology
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Sebastian PomplunFaculty of Science
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Boosting the immune system to fight anitibiotic resistant Tuberculosis
Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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Robust rules for prediction and description.
In this work, we attempt to answer the question:
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Freek Vonk gets his own show on Discovery Channel
Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…
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The archaeological discovery at the Paardenmarkt in Alkmaar
In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.
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Will this discovery help us develop better catalysts?
Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…