Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: M.A.G.J. Orrit

Formulation of biopharmaceuticals

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

We are a community of researchers from diverse backgrounds who explore becoming and being human, in relation to the world around us and other living beings.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This multidisciplinary minor addresses the fascinating question how we, modern humans, got to be the way we are. Who were our ancestors? How does our morphology, genetic makeup, brain and behaviour relate to that of other species? How does our evolutionary past affect our susceptibility to diseases?…

When you stretch an elastic band, it gets longer. But imagine a material that actually becomes shorter when you pull on it. Sounds strange, doesn’t it? Yet that’s exactly what physicists from Leiden University, AMOLF, and ARCNL have managed to create.

Leiden University is 444 years old this year! And we have big plans to celebrate this special birthday in 2019 - together with the people of Leiden and The Hague.

Every year diplomatic representatives of Latin American countries, researchers and students come together during a conference of the GRULAC region group. This year different researchers talked about their work during a visit to the Faculty of Governance and Global Affairs in The Hague.

It is still not easy to ‘come out’ about your sexual orientation or gender identity. On Coming Out Day (11 October), the issue was the focus of global attention. This year, instead of the traditional rainbow flag, the ‘progress pride flag’ flew above University buildings.

Water droplets float in a hot pan because of the so-called Leidenfrost effect. Now physicists have discovered a variation: the Elastic Leidenfrost effect. It explains why hydrogel balls jump around on a hot plate making high pitched sounds. Publication in Nature Physics on July 24.

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…

Are you intending to become a student shortly? And are you unsure about what you're going to study? If so, come to the Open Day on 15 October.

This fall, LUCIS will have the pleasure of welcoming Professor Maribel Fierro, Research Professor at the CSIC (Consejo Superior de Investigaciones Científicas, Madrid), to Leiden. She is the third Abdulaziz Saud Al-Babtain Cultural Foundation Visiting Professor in Arabic Culture at Leiden University…

Want to find out how to assemble a human skeleton? Do you know what chemistry can be found around you? And are you easily fooled by fake news? Discover this and more at our Science Fair on 3 October.

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Man is nature's mind-reading champion: we are better able than any other living beings to empathise with others. This comes in part from our story-telling culture, according to Max van Duijn. PhD defence 20 April.

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

A full overview of MCBIM PhD theses.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

We study the structure, dynamics and physics of complex networks emerging from the intricate interconnectedness of the constituents of large systems.

Education & outreach

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

Researchers of the National University of Singapore and Leiden University have discovered that chimpanzees and bonobos share the contrasting colour pattern seen in human eyes, which makes it easy for them to detect the direction of someone’s gaze from a distance.

Management of Impacts on Biodiversity: What are the effects of light pollution from cities and bridges and noise pollution from passing vessels and nearby road traffic on migratory fish passage and spawning in rivers?

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

The knowledge and skills you will acquire will qualify you for many different jobs. Possible careers include: researcher of learning, behavioural and emotional problems in children, or designer of prevention and intervention programmes.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.