242 search results for “enzyme” in the Public website
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Awards and Grants 2023
On this page you will find an overview of awards and prizes granted to our staff and students in 2023, as well as special appointments at Leiden University and other institutions.
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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Finding unique drug structures with artificial intelligence and chemistry
In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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How do you determine the right medicine dosage for a child?
What’s the right dosage of medication for children? Assistant professor Elke Krekels and her colleagues discovered that for some medicines, you can determine this quite simply. On 13 April Krekels received the TOP-Publication award during the annual spring meeting of the Dutch Society for Clinical Pharmacology…
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Leiden Medicinal Chemistry researcher Andreas Bender receives prestigious EFMC Prize
Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the
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In Memoriam Arne van der Gen
On January 11, 2025, our esteemed colleague and emeritus professor Arne van der Gen passed away. Arne was a professor of Organic Chemistry from 1980 until his retirement in 2000, and was a great advocate of the integration and harmonization of European education in chemistry. Arne was 90 years old.
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17.9 million euro for national NMR Roadmap consortium
The National Roadmap for Large-Scale Research Facilities programme of NWO enables the building or renovation of research facilities with international allure. Leiden NMR groups take part in the uNMR-NL consortium coordinated by Marc Baldus (Utrecht University) that has been awarded almost 18 million…
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Tracing cancer with a simple blood test
Thanks in part to the persistence of a Leiden research group, cancer could be detected in the near future with just a single drop of blood. Not only can the diagnosis be determined at an earlier stage, but the blood test is also cheap, fast and patient friendly. The first results of this method seem…
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‘How can we translate the language of cells into cancer therapies?’
On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…
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Experimental drug BIA 10-2474 deactivates proteins in human nerve cells
At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…
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Plastic's Legacy: From Single-Use to Sustainable Solutions
Lecture, Studium Generale
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Dennis ClaessenFaculty of Science
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LED3 Lecture: Production of supply-limited natural product therapeutics using engineered yeast
Lecture
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Awards and Grants 2020
An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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Wrestling with SUMO proteins
The work done by SUMO proteins in the cells of our body is of vital importance. Molecular cell biologist Alfred Vertegaal has been studying these proteins for nine years, first with a Veni subsidy and then with a prestigious Vidi subsidy.
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Five Leiden professors elected to KNAW
The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.
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New technique offers chemists unprecedented control in drug research
Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…
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Vici grant for Jeroen Codée: ‘I want to understand how sugars are formed’
Although sugars are widely used in biological and medical research, their synthesis is still badly understood. Jeroen Codée has received a Vici grant of 1.5 million euros for systematically studying the production of sugars. ‘I want to genuinely understand the reactions.’
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Unraveling the mysteries of Multiple Sclerosis
Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.
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Proteomics and functional investigation of SUMO and ubiquitin E3 ligases
PhD defence
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L(SB)2 Seminar: Promiscuous NAD-dependent dehydrogenases enable efficient bacterial growth on the PET monomer ethylene glycol
Lecture
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LIC Lectures
Lecture
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LIC Lecture + drinks
Lecture
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LIC Guest Lecture: Controlling biological systems: From nanopore-forming toxins to a chemical-genetic system to map ZDHHC-specific S-acylation
Lecture
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Reedijk Symposium 2025: Induced Proximity Drug Modalities: Hijacking Mother Nature to Control Protein Function
Lecture
- De Novo Cyclic Peptides: A RaPID Approach to Chemical Tool Development
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Subsidies for high-grade research facilities
Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…
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LED3 Lecture: Targeting Post-translational Modification for Drug Discovery
Lecture
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Unraveling proteoform complexity by native Liquid chromatography - mass spectrometry
PhD defence
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L(SB)2 Seminar: Conformational regulation of the GTPase-interacting ubiquitin ligase HACE1
Lecture
- Publication highlights
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Reedijk Symposium 2025 poster session
Conference
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Antiviral strategies against emerging coronaviruses
PhD defence
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L(SB)2 Seminar: Discovering new heparanase inhibitors through X-ray Crystallography
Lecture
- IBL Spotlight - Han de Winde and IBL Analytical Facility
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LED3 PhD-Postdoc Symposium 2024
Conference
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Hall of Fame 2020
In 2020, many of our staff and students have again won prestigious prizes and been awarded important research subsidies.
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.