This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

This project investigates properties of quantity expressions across languages from the perspective of how quantity is represented in the human brain.

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

Our facilities cover:

In the large gas clouds between the stars, chemical reactions take place under extreme conditions, giving rise to both small molecules, such as water and common salt, as well as large complex molecules that can serve as the building blocks of life. This is known as astrochemistry and it is something…

The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…

The central research question focuses on identifying shifts in the urban social network in terms of private, semi-public and public space by means of mapping the spatial distributions of wells and cesspits in the town of Haarlem in the course of the pre-industrial period (1200-1800). Shifts may be indicative…

What happens to the different waste streams?

How did Angkor interact with regional urban centers? How did the settlement system impact the society's agricultural system and regional resilience?

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Pathways of toxicity

Analysis of drug adversity

The Advisory Board is an external Advisory Council, to advice the Board of Directors of CML about general strategies, research and education activities and evaluation procedures (Dutch: visitatie).

Lets hit the water! Our students joined us on Saturday 30 August 2025 for a Stand Up Paddleboarding (SUP) and canal clean-up session on Leiden’s canals with Plastic Soup Surfer Merijn Tinga.

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

What is Leiden University doing to make its buildings future-proof and independent of fossil energy?

Leiden University purchases a wide range of goods and services every year. To a greater or lesser extent, they all have an environmental impact.

During the farewell reception on 29 August, the Faculty of Science will say goodbye to Dean Geert de Snoo. On 1 November 2019, he will continue his career as Director of the Netherlands Institute of Ecology (NIOO-KNAW). Colleagues talk about his significance for ecology, about his contribution as a…

À La Découverte de la Hollande dans les années 1760-1770 : Pierre Famin, Emmanuel de Croÿ-Solre, François-César Le Tellier, Jean-Marie Roland de la Platière, Gabriel-François Coyer. Textes réunis et présentés par Madeleine van Strien-Chardonneau, Paris, Société française d’étude du dix-huitième siècle,…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

The Great Rift Valley in Africa is a real treasure trove for discovering early human fossils. The fossils found in this part of Africa have determined our view of human evolution. But was the Great Rift Valley really the place where evolution took place or just a place where fossils are well preserved…

The renovation of the Herta Mohr building (formerly known as Cluster Zuid) is completed. It is the third project in the redevelopment of the Humanities Campus. With the renewal of these buildings, the university ensures a sustainable campus with modern facilities. The university wants to create an attractive…

Lecture

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…

High throughput microscopy

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

Promotor: Prof.dr. H.L.V. Linnartz

Both on a personal and institutional level, the staff of Leiden CADS collaborates with:

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Mechanisms fro drug resistance

Schuurman examines how Russia is escalating its covert operations against European countries.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

During the development of the Humanities Campus, many aspects of sustainability are combined. For example:

Discovery of metastasis promoting candidate drug targets

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

In September 2023, we started transforming a under-utilised outdoor space into a greener and more biodiverse garden in which all students and staff of the Schouwburgstraat can relax and enjoy.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Sustainable energy from wind and solar is most readily available near the sea.

Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…