Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.

Patients on patient forums share all sorts of things about their illness: from side effects and advice to messages of support. PhD candidate Anne Dirkson uses artificial intelligence (AI) to retrieve this information. ‘Ninety per cent of the side effects weren’t officially registered.’

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

Using N2 dissociation on Ru(0001) as a representative showcase (for catalysts employed in the Haber-Bosch process), we have shown for the first time that non-adiabatic effects can substantially reduce a molecule’s dissociation probability on a metal surface. These effects are currently completely unaccounted…

Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

We are all aware of the importance of a healthy lifestyle. However, at the same time we also experience many difficulties when we are trying to change our behavior to become more healthy. For example, more often than not our good intentions to exercise more or to eat fewer unhealthy snacks fail miserably…

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Mark Klaassen presenter at the Reuniting Families: From Access to Integration event organized by the EU office of the Red Cross in Brussels.

Storm clouds are gathering for the European grants for ‘excellent’ research. Researchers therefore need to explain how important these grants are. This is what Jean-Pierre Bourguignon, President of the European Research Council (ERC), had to say during a visit to Leiden University on Thursday 24 Apr…

By reforming agriculture in targeted areas, we can protect the Natura 2000 areas much more effectively. This is what Jan Willem Erisman of Leiden University and Ton Brouwer of Gispoint consultancy write in a new report. They have created a special, nitrogen map of the Netherlands that shows the areas…

Viktorija Kostadinova, from Macedonia and currently a second-year PhD student at the Leiden University Centre for Linguistics, has just returned after two and a half months at the University of Michigan: ‘It was a truly rewarding experience.’

How is interdisciplinary collaboration faring at Leiden University? And has disciplinarity been completely abandoned? I’d like to reflect on some concerns among colleagues and on our plans for the future.

The annual conference of the Global Transformations and Governance Challenges (GTGC) interdisciplinary research programme will take place in The Hague on 7-9 June. Why should you be there? ‘The problems in the world affect us all. This conference will be looking at planetary governance’, says programme…

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

In this blog post Saskia Postema and Jan Melissen claim that Chinese UN celebrities’ activism under Xi Jinping has become aligned with the Chinese leadership’s ambitions.

Prof. Andrea Evers is a health psychologist who studies the role of behavioural factors in health and disease. As a Medical Delta Professor, she is now affiliated with Leiden University, TU Delft and Erasmus University. In that position, she conducts research at the intersection of various disciplines.…

The Hazelhoff Centre for Financial Law organized the third edition of the workshop ‘Principles for effective negotiations in legal practice’ on 5 June 2018.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

How do digital technologies affect adolescent mental health and resilience? How do we foster a secure online environment? How should we deal with increasing rates of online crimes among adolescents? During the mini-symposium ‘The effect of the online world on adolescents’, presented by the interdisciplinary…

New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Promotor: Prof.dr. M. Danhof

How does ICT affect society? Mirjam van Reisen, professor Computing for Society at the Leiden Centre of Data Science, is intrigued by this question. We speak with her about innovation, changes in health care, and mobile human trafficking. ‘Innovation has many benefits, but it can also be very disrup…

Research into our history of colonialism and slavery, heart-to-heart conversations at a Keti Koti table, exhibitions, lectures and podcasts that establish the link between present and past. Staff and students participated in the national Slavery Memorial Year in many different ways. What have we learned…

On 29 October, seven innovative lecturers from different faculties will join the existing ten fellows of the Leiden Teachers' Academy. The current fellows have been engaged for the past year in implementing their innovation projects. How are these progressing?

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Indonesian Law and Reality in the Mahakam Delta

Regular users of cannabis are less aware of their own mistakes, and they are not good at creative thinking. This is the conclusion drawn by psychologist Mikael Kowal from his research on the effects of cannabis. PhD defence 6 October.

This research line is part of the living lab of the University’s Population Health interdisciplinary program, located at the LUMC Campus The Hague, where the Leiden University Medical Center collaborates with the Faculty of Governance and Global Affairs and the Faculty of Social and Behavioral Sciences…

The Institute of Psychology is responsible for innovative and interdisciplinary research and education within psychology and related disciplines.

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

Promotor: C.U. Keller, Co-Promotor: F. Snik

Psychologists Fenna Poletiek and Erik de Kwaadsteniet have received a grant from the FNV trade union to research people’s attitude to work if they receive a basic income. How do they plan to find answers?

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

The fourteen Dutch universities have published a digital magazine in which the researchers explain the Digital Society programme in text and images.

Promotor: Prof.dr. G.J. Kroes

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)