A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

EuDEco (modellering van de Europese Data Economie) is een Coordination & Support Action (CSA) die financiering ontvangt van het Europese Horizon 2020 programma.

Consequences for sediment stability and seston trapping

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: J. Aarts

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.