251 zoekresultaten voor “title therapy” in de Publieke website
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
- Agenda
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Marike KooistraFaculteit der Sociale Wetenschappen
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Understanding anthracycline action: molecular insights to improve cancer therapy
Promotie
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Refractory Celiac Disease: from basic insights to therapy
Promotie
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Risk assessment tools and adjuvant therapy for breast cancer
Promotie
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T-cell gene therapy for low mutational burden cancer
Promotie
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Risk assessment tools and adjuvant therapy for breast cancer
Promotie
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Improving CD3 bispecific antibody therapy for solid cancer
Promotie
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Onderzoek
Het doel van ons onderzoeksprogramma Klinische Psychologie is om de etiologie en het verloop van stemmings-, angst- en stress-gerelateerde aandoeningen zoals depressie en posttraumatische stressstoornis (PTSS) beter te begrijpen.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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The gendered micropolitics of hiding and disclosing: assessing the spread and stagnation of information on two new EMTCT policies in a Malawian
Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Extracellular Matrix Mechanics in the Regulation of the early steps of the Metastatic Cascade
Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.
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Judith BovéeFaculteit Geneeskunde
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Partners
Ons onderzoeksprogramma werkt samen met allerlei partners om ons doel, het zo snel mogelijk naar de kliniek brengen van wetenschappelijke ontdekkingen, te bereiken.
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Welkom bij de Leidse Faculteit der Sociale Wetenschappen
Actuele vraagstukken uit zowel Nederland als de internationale gemeenschap, zetten we in om de nieuwsgierigheid van studenten en onderzoekers te prikkelen.
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Lioe-Fee de Geus-OeiFaculteit Geneeskunde
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Rick HaasFaculteit Geneeskunde
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John HaanenFaculteit Geneeskunde
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Eveline BleikerFaculteit Geneeskunde
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Redirecting TGF-β signaling pathways: Advancing targeted therapy for PAH and FOP
Promotie
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Navigating Complexities in Implantable Cardioverter-Defibrillator Therapy: Insights, Challenges, and Patient-Centred Approaches
Promotie
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Imaging and high-dose proton therapy in chordomas and chondrosarcomas of the axial skeleton
Promotie
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as universal cell source for kidney regeneration in transplantation therapy
Promotie
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Exercise is medicine: longstanding exercise therapy in people with axial spondyloarthritis and severe functional limitations
Promotie
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Towards individualizing anticoagulant therapy - Understanding risk factors for thrombosis and bleeding
Promotie
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The impact of neoadjuvant systemic therapy on the surgical management of soft tissue sarcoma
Promotie
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expectations: inhibitory learning and change processes in exposure therapy for PTSD
Promotie
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Alumni
In de afgelopen jaren hebben er veel verschillende mensen meegewerkt aan de projecten binnen de Dappere Kleintjes onderzoekslijn. Zie hieronder een overzicht van onze alumni.
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Marjanka SchmidtFaculteit Geneeskunde
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Jeroen JansenFaculteit Geneeskunde
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Alfred VertegaalFaculteit Geneeskunde
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Zuid-Afrika: geschiedenis van een land in worsteling
Deel één van The Cambridge History of South Africa van Leids historicus Robert Ross e.a. heeft een plaats gekregen op de lijst van Outstanding Academic Titles van de invloedrijke American Library Association. Het standaardwerk uit 2010 geeft een nieuw perspectief op de geschiedenis van Zuid-Afrika tot…
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Zuid-Afrika: geschiedenis van een land in worsteling
Deel één van The Cambridge History of South Africa van Leids historicus Robert Ross e.a. heeft een plaats gekregen op de lijst van Outstanding Academic Titles van de invloedrijke American Library Association. Het standaardwerk uit 2010 geeft een nieuw perspectief op de geschiedenis van Zuid-Afrika tot…
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in Type 1 Diabetes: Implications for Pathogenesis, Complications, Therapy and a Cure
Promotie
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Advancing host-directed therapy for Mycobacterium avium infection: identification of drug candidates and potential host targets
Promotie
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James HardwickFaculteit Geneeskunde
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Joan Hendrik VeelkenFaculteit Geneeskunde
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Piet PostmusFaculteit Geneeskunde
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Coen RaschFaculteit Geneeskunde