Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Op 7 september verdedigde Francesc Claret Traid het proefschrift 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. Het promotieonderzoek is begeleid door Afshin Ellian en Gelijn Molier.

Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.

Barrie Sander identificeert verschillende risico’s en zorgen rondom het gebruik van kunstmatige intelligentie om klimaatverandering aan te pakken.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

In dit artikel onderzoekt Rutger Leukfeldt, bijzonder hoogleraar Governing Cybercrime, met collega's de relatie tussen PMT-factoren en zelfbeschermend onlinegedrag.

De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotor: Prof.dr. R.M.H. Merks

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: Prof.dr. M. Ubbink

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Didactiek

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Het blijkt dat de nieuwe minor S&RBB erg populair is onder de eerstejaars studenten.

Alvast oefenen in de boardroom en start ups door spannende tijden loodsen. Studenten van Harmen Jousma, docent Science Based Business, leren de kunst van het ondernemen al in de collegebanken. Jousma is een van de drie genomineerden voor de Leidse Onderwijsprijs.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.