Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotor: Prof.dr. E. F. van Dishoeck

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Stel je voor: we kunnen met duurzame energie het broeikasgas CO2 omzetten in synthetische brandstoffen. Dan verminderen we én de hoeveelheid CO2, én we hebben een nieuwe manier om bijvoorbeeld wind- en zonne-energie op te slaan. Chemicus Akansha Goyal (Universiteit Leiden) doet fundamenteel onderzoek…

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

We kunnen bijna 100 miljard ton CO₂ uit de atmosfeer halen nog voor de eeuw om is. Dat wil zeggen, als hoge-inkomenslanden overschakelen op een plantaardig dieet. Landbouwgrond voor veeteelt terugbrengen in zijn oorspronkelijke staat levert dubbele koolstofwinst op: gelijk aan ongeveer 14 jaar agrarische…

In 2050 moet de overstap naar nieuwe, duurzame energiebronnen zijn voltooid. Wetenschappers van de Universiteit Leiden verrichten vanuit diverse disciplines uniek onderzoek dat bijdraagt aan deze transitie en de reductie van CO2.

Voor de bedrijfsvoering van de Universiteit Leiden is duurzaamheid een belangrijk onderwerp, zeker als we kijken naar de CO2-footprint, duurzame energie en vergroening van gebouwen.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: W. Jiskoot, Co-promotor: H.A. Every

From Incident to Precedent

Individuele moleculen zijn extreem moeilijk te zien via hun zwakke fluorescentie. Piepkleine gouden nanostaafjes fungeren als nieuwe antennes om hun signaal 500 maal te versterken. Publicatie op 24 februari in Angewandte Chemie.

De Universiteit Leiden werkt aan een groene, circulaire campus, met een forse energiereductie in 2050 als doel, zoals uitgewerkt in de in 2022 verschenen Routekaart energietransitie gebouwen.

Om fase 2 te realiseren worden er diverse gebouwen gesloopt.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: Prof.dr. H.V.J. Linnartz

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: Prof.dr. H.L.V. Linnartz

Een consortium van internationale wetenschappers komen met een unieke oplossing voor het energieprobleem. Door fotosynthese na te bootsen hopen ze duurzame brandstoffen te maken uit zonlicht, water en CO2. Hun geheim? ‘Zeepbellen’, zegt Leidse chemicus Sylvestre Bonnet, die deel uitmaakt van het con…

Een techniek om CO2 om te zetten in brandstoffen en andere nuttige producten, is elektrolyse. Om dit efficiënt en op grote schaal te kunnen doen, moeten we wel precies begrijpen hoe elektrolyse werkt. Hoogleraar Marc Koper is expert op dit gebied.

Benieuwd hoe duurzaamheid past in het strategisch plan van onze universiteit, of hoeveel energie en water we verbruiken? Lees er hier meer over.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Wat doet de Universiteit Leiden om het energieverbruik te reduceren en af te stappen van fossiele energie? Waar vind je informatie over energie? En hoe kan je zelf aan de slag?

Onder de gezamenlijke titel ‘Scarcity and the State’ verschenen onlangs twee Engelstalige boeken over de verdeling van schaarse publieke rechten (Intersentia 2016). Paul Adriaanse (UL), Frank van Ommeren (VU), Willemien den Ouden (UL) en Johan Wolswinkel (Tilburg University) voerden de redactie. Aan…

Hoe kunnen dure en zeldzame materialen beter worden gebruikt om schonere brandstof goedkoper te produceren? Onder leiding van Marc Koper, hoogleraar katalyse en oppervlaktechemie, publiceren internationale teams van wetenschappers 3 publicaties in Nature Communications.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Promotor: J. Schaye

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.