The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Jaroslaw Kantorowicz and Rok Spruk onderzoeken de bijdrage van institutionele hervormingen aan economische groei.

Religion and ethnicity are inextricably linked in discourse within and about Central Asia. One common narrative suggests that as a result of differences between historically sedentary and nomadic populations, ethnic Tajiks and Uzbeks are naturally more religious and more likely to radicalise than their…

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

Promotie

In dit proefschrift onderzochten we hoe we kankerbehandelingen slimmer en veiliger kunnen doseren. Veel middelen worden nog volgens een “one size fits all”-schema gegeven, vaak gebaseerd op de maximaal verdraagbare dosis. Dat kan leiden tot onnodig veel bijwerkingen, behandelingonderbrekingen en hoge…

Promotie

Promotie

Promotie

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Workshop

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Caroline van Eck ontvangt in maart 2014 de Descartes-Huygensprijs: een verblijf als gastonderzoeker in Frankrijk. Van Eck krijgt de prijs voor haar excellente onderzoek en haar bijdrage aan de Frans-Nederlandse samenwerking.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Hybrid Symposium: Medieval miniatures from Byvanck to the RKD. 18 March 2025, Den Haag.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Consequences for sediment stability and seston trapping

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

Workshop

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.