This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

Promotor: S.J. Edixhoven

Een virtuele hand die voelt alsof het je eigen hand is. Je vrolijker voelen omdat een virtueel gezicht samen met jou glimlacht. Psycholoog Ke Ma ontdekte met virtual reality dat ons lichaamsgevoel flexibeler is dan gedacht. Ke Ma: ‘We kunnen fantastische applicaties bedenken.’

In dit proefschrift wordt gekeken naar de produktie en consumptie van het reality-tv-programma ‘Nieuwe Wijze Oom’. Deze show, uitgezonden op het entertainmentkanaal van de provincie Shanghai, draait om mediation in conflicten tussen burgers. ‘Nieuwe Wijze Oom’ is geliefd bij het publiek én bij de autoriteiten.…

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Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

Quantum computing represents a fundamentally new computational paradigm, capable of addressing problems that are intractable for classical computers.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Promotores: F.H.J. Redig, W.T.F. den Hollander

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Promotor: Prof.dr. G.J. Kroes

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Hoe kan complexiteitswetenschap de transformatie van inlichtingen bevorderen?

Aan de hand van een reeks case studies in Irak, Moldavië en Servië gedurende het post-Koude Oorlogstijdperk, onderzoekt dit boek asymmetrische conflicten waarbij de strijdende partijen een grote ongelijkheid in machtsposities vertonen.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

An interdisciplinary collection of the best international scholarship on Muslim youth.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Curved single crystals provide variable, but well-defined surface structures.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…