Onderzoeker Mario van der Stelt van onderzoeksinstituut Oncode heeft met zijn medewerkers een nieuw potentieel geneesmiddel (stofnaam: LEI-515) ontdekt dat door chemotherapie veroorzaakte neuropathische pijn onderdrukt.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Promotor: W. Jiskoot, Co-promotor: A. Kros

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Promotor: Prof.dr. G.P. van Wezel

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Een Nederlands consortium ontvangt 6,7 miljoen euro om samen met patiënten het ontwikkelen van nanomedicijnen te versnellen. Onderzoekers van de Universiteit Leiden spelen daarbij een belangrijke rol.

Promotor: A. Kros

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: M. Ubbink, Co-promotor: G. Siegal

Biotechbedrijf Toxys, de Universiteit Leiden en het Leids Universitair Medisch Centrum gaan samen de door hen ontwikkelde ToxProfiler-technologie op de markt. ToxProfiles maakt het mogelijk snel de potentiële giftigheid te bepalen van nieuwe en bestaande geneesmiddelen, chemicaliën en andere stoffen.…

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. M. Danhof

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Prof.dr. M.K. Richardson

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: Prof.dr. B. van de Water

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. M. Danhof

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. J. Kuiper

Cardiovascular disease is the leading cause of death worldwide.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…