Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: Prof.dr. G.R. de Snoo

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: W. Jiskoot, Co-promotor: H.A. Every

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotor: Prof.dr. J. Kuiper

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotor: A. Kros

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotor: M.L. van Hecke

Promotores: T.H. Oosterkamp, N. de Jonge

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Plants rely on multilayered immune systems to detect and restrict pathogen invasion while minimizing damage to host tissues. This thesis investigates the regulation, spatial organization, and functional consequences of effector-triggered immunity (ETI) in Arabidopsis thaliana.

Climate change is increasingly threatening agriculture, as rising temperatures cause major losses in crop productivity. Plants, however, have a remarkable ability to “remember” previous heat stress.

Als meisje van zes jaar oud wist Barbara Gravendeel het zeker: ze wilde bioloog worden. Het zaadje hiervoor werd geplant in de tuin van haar ouderlijk huis. Een oude hoogstamboomgaard met een enorme haag eromheen. Sinds 1 mei is ze wetenschappelijk directeur (prefect) van de Hortus botanicus en vallen…

Op 8 oktober vond in het Kamerlingh Onnes Gebouw van de Universiteit Leiden een inspirerende sessie plaats rondom het bekroonde boek The Story of Constitutions van Professor Wim Voermans, recent uitgegeven door Cambridge University Press. Het event trok een gemengd publiek van collega’s en studenten…

The global agri-food system plays a critical role in food security and environmental issues.

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

Het Leiden Advocacy Project on Plastic (LAPP) is een pro bono initiatief aangaande juridische vraagstukken omtrent plastic. LAPP is opgericht om het toenemende probleem van plasticvervuiling aan te pakken en onderzoek te doen naar juridische kwesties gerelateerd hieraan. Studenten werken hierbij als…

Promotor: Prof.dr. G.J. Kroes

Video games have emerged as one of the most interesting media of the turn of the century. The peculiar characteristic of video games is the biunivocal interaction between the computer and the human player.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Welke invloed hadden binnen de linkse actiebewegingen in de periode 1965-2015 de interne discussies over gebruik van geweld én de overheidsrespons op dit (politieke) geweld op de ontwikkeling, het niveau en de continuïteit van het uit deze bewegingen afkomstige geweld?

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Matthias Haentjens, Jouke Tegelaar en Dorine Verheij schreven het hoofdstuk Financial Market Regulation and Supervision, dat recentelijk is gepubliceerd in het belangwekkende handboek The Law of the European Union (voorheen Kapteyn & VerLoren van Themaat).

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Het team van het Hazelhoff Centre for Financial Law publiceert regelmatig in zowel Nederlandse als internationale wetenschappelijke tijdschriften en boekreeksen.

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De sociale angststoornis is één van de meest voorkomende stoornissen bij kinderen en jongeren. Sociale angst wordt gekenmerkt door overmatige angst en vermijding van sociale situaties, waarbij kinderen voornamelijk bang zijn om negatief beoordeeld te worden door anderen. Cognitieve gedragstherapie,…

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.