Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. T. Hankemeier

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Afgestudeerden van de masterspecialisatie Onderwijs en Opvoeding in een Digitale Wereld aan de Universiteit Leiden zijn goed voorbereid op uiteenlopende functies. Zij kunnen bijvoorbeeld kindertherapeuten adviseren over e-healthtoepassingen, scholen begeleiden bij het gebruik van digitale middelen en…

Promotor: Prof.dr. P.C. van Welzen

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Hydrogen-based fuels are regarded as promising candidates for decarbonizing the maritime shipping sector.

Gendergerelateerd geweld is een urgent maatschappelijk probleem dat jaarlijkse vele levens ingrijpend raakt. De ernst en complexiteit ervan vragen om een doordachte en professionele aanpak, met oog voor slachtoffers, daders, de context en het systeem.

Het onderwerp van dit proefschrift is integratie van klinische kennis en kennis van de basisvakken in het medisch onderwijs en de rol die concept maps kunnen spelen in het expliciet maken van deze zogenoemde verticale integratie.

Deze opleiding biedt de mogelijkheid top onderzoek in de natuurkunde te combineren met ondernemerschap, technologie management, innovatiebeheer en besluitvorming in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid om biologie-onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

In het programma ‘Verder met publiek leiderschap’ werken het Leiden Leadership Centre van de Universiteit Leiden en verschillende publieke organisaties samen om leiderschap goed te onderzoeken en verder te ontwikkelen. Leiderschapsontwikkeling wordt daarmee evidence-based en wetenschappelijk onderzoek…

Deze opleiding biedt de mogelijkheid om sterrenkundig onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid om top onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid top onderzoek in de wiskunde te combineren met ondernemerschap, technologie management, innovatiebeheer en besluitvorming in het bedrijfsleven.

Wat is het effect van maatschappelijke veranderingen, persoonlijke levensomstandigheden en migratiebeleid op iemands besluit te migreren?

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

Wat zijn de kenmerken van impactvol onderwijs voor de toepassing van inclusieve ontwerpprincipes door studenten in ontwerp- en technologieprogramma's?

The dissertation describes TEM experiments on heterogeneous catalysts.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Het domein Diversiteit en Inclusie bestaat uit een leergang Diversiteit & Inclusie en een masterclass Inclusieve Communicatie. Daarnaast is het mogelijk een training aan te vragen op maat voor een bedrijf of organisatie, de zogenaamde 'incompany training'. De D&I leergang die bij het Centre for Professional…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.