OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Dit proefschrift gaat over theoretische oppervlakte chemie binnen het veld van de heterogene katalyse.

Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…

Een onderzoek naar de invloed van afgeleid eten op consumptiebeleving en het consumptiegedrag.

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

In de grote gaswolken rondom jonge sterren vinden onder extreme omstandigheden chemische reacties plaats. Daarbij ontstaan zowel kleine moleculen, zoals water en keukenzout, als grote, complexe moleculen die kunnen fungeren als bouwstenen van het leven. Deze astrochemie onderzoeken we in Leiden met…

Leidse wetenschappers onderzoeken groepsgedrag. Ze ontdekten onder meer dat mensen zich waarschijnlijk instinctmatig opofferen voor een mede-groepslid. Met dit soort inzichten kunnen we sociale processen in een wijk of binnen een bedrijf beter begrijpen en beïnvloeden.

Op welke manier kunnen docenten de betrokkenheid van studenten ondersteunen en vergroten in de context van blended learning?

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Mechanical interactions between cells and their environment play an important role in many biological processes.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Promotor: W.Th.F. den Hollander

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Als je het menselijk verleden bestudeert, kan dit je helpen om de maatschappelijke vraagstukken van tegenwoordig beter te begrijpen en op te lossen.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Leerdoelen Leergang Cybersecurity

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

Hoe kunnen we op een interdisciplinaire wijze de classificatie van migranten en mensen met een beperking bestuderen en onderzoekers van deze velden samenbrengen om raakvlakken met elkaar te vinden?

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

Hoe kunnen we kwaliteit van leven en studiesucces vergroten bij jonge, hoog-functionerende volwassenen met autisme?

Wij bestuderen de dagelijkse praktijk van individuen, groepen en gemeenschappen - zowel in Nederland als wereldwijd - om ze te plaatsen binnen de complexe processen van sociale en globale ontwikkeling. In Leiden zijn we gespecialiseerd in de gevolgen van globalisering op het milieu, de sociale verhoudingen,…

Niets heeft zo’n invloed gehad op het verloop van de wereldgeschiedenis als de grote metamorfose van de menselijke samenleving in de afgelopen tweehonderd jaar.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Open Science en Erkennen & Waarderen komen samen in dit universiteitsbrede programma.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Het is voor scholen in toenemende mate een forse uitdaging om uitval van docenten op te vangen. Het lerarentekort benadrukt het belang van een ondersteunende werkomgeving en sterke binding tussen docent en school.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.