Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Plastics have become an integral part of modern society due to their versatility and durability.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Antibioticaresistentie is een van de grootste bedreigingen wereldwijd voor de volksgezondheid in de komende decennia.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Er zijn veel studies waarmee je kunt instromen in de master Health, Ageing and Society! Veel gezondheidsgerelateerde opleidingen zijn direct toelaatbaar, maar je bent ook welkom met een andere studieachtergrond.

Hoe detecteren bacteriën signalen uit hun omgeving en hoe passen ze zich daaraan aan? Die vraag intrigeert Ariane Briegel, hoogleraar Ultrastructuurbiologie. Met behulp van nieuwe technieken produceert ze driedimensionale beelden, die nieuwe informatie geven over het zintuiglijke systeem van bacteri…

Promotie

Boeren die zich committeren aan natuurvriendelijk werken, zetten zich in de praktijk ook daadwerkelijk in voor agrarisch natuurbeheer – vooral wanneer dit niet gefinancierd wordt door de overheid. Dit blijkt uit onderzoek van Anne Marike Lokhorst, waarop ze 17 september promoveert.

In hoeverre hopen nanodeeltjes zich op in planten en dieren, en welke eigenschappen van de deeltjes spelen hierbij een rol? Willie Peijnenburg, hoogleraar Milieutoxicologie en biodiversiteit kreeg een Marie-Curie beurs toegekend om onderzoek te doen naar de milieueffecten van nanodeeltjes.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: G.A. Persoon, H.H. de Iongh

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Zelf met leerlingen aan de slag in een zoektocht naar antibiotica? Met het practicum Antibiotica Gezocht! gaan bovenbouw havo- en vwo-leerlingen tijdens de biologieles op zoek naar (nieuwe) antibioticum-producerende bacteriën.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Boek over bestrijdingsmiddelen en waterkwaliteit

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel