We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

For a successful implementation of an educational reform, teachers need to regard the proposal as being practical. I used a modular, success-oriented approach to make a context-based reform practical for implemtentation in Duthc biology education. educational reform, modular, teachers, biology, success-oriented,…

On 17 April, Evert-Jan Govaers defended the thesis 'Ministers of State. Unknown and desired; from stage to the wings?'.The doctoral research was supervised by Wim Voermans.

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Managing scarcity to serve the public interest is a classic government task. An important way to execute this task is by allocating individual rights that are only available in limited quantities, such as CO2 emission allowances, gambling licences, subsidies, radio frequencies, public contracts and…

This article provides a comprehensive analysis of the Islamic State's use of images taken by drones, drawing on a dataset of ISIS propaganda images from October 2016 to December 2018.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.

PhD defence

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

PhD defence

PhD defence

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

State Building Through Life Stories: Incorporating Local Perspectives

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

This edited volume by Jeff Fynn-Paul pushes forward the debate on the role of entrepreneurs in making war and building states in Europe and the Ottoman Empire.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

The States, Markets, and Civil Society department of the Institute of Public Administration examines how politics and governance, businesses, citizens, and societal organisations collaborate to address major societal challenges. This includes issues such as inequality, migration, and sustainability.

Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

The Europa Instituut is pleased to announce that on 21 November 2016 a new handbook “EU State Aids” (31 Chapters, 1500 pages) was published.

In this article, Samir Negash, PhD candidate at the Institute of Public Administratation, discusses the discrepancy in European countries between the measured impact of immigration on the welfare state and how this impact is perceived by citizens.

The nation-state is not so old as we are often told, nor has it come to be quite so naturally. Getting this history right means telling a different story about where our international political order has come from—which in turn points the way to an alternative future.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

This study examines how European state administrations responded to transboundary crises over the past 30 years and the extent of their successful adaptation.

This dissertations studies state-society relations in 1930s Turkey, focusing on the anti-veiling campaigns in the mid-1930s and aiming to understand the ways in which the Kemalist policies were received, interpreted, negotiated, compromised and/or resisted by various actors in the provinces.

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

On 21 September 2022 Arfiansyah successfully defended a doctoral thesis and graduated.

Recent years have seen a vibrant scholarship on health policy and politics. While much is now known about changes to health policies and institutions over time, this study finds that scholarship still lacks research on the linkages between health policies and health outcomes (Marmor & Wendt, 2012).…

Latif Fauzi defended his thesis on 18 May 2021.

All players on the world stage operate strategically in order to safeguard their interests. Political scientists at Leiden University cast light on this volatile interplay of forces. Their research helps voters, NGOs, governments and international organizations make smart choices in this complex and…

In the wake of controversial disclosures of classified government information by WikiLeaks and Edward Snowden, questions about the democratic status of secret uses of political power are rarely far from the headlines. Despite an increase in initiatives aimed at enhancing government transparency – such…