Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

De master Literary Studies van de Universiteit Leiden biedt een gespecialiseerde kwalificatie in één van vier talen (Engels, Frans, Duits en Italiaans) en culturen, of een vergelijkend perspectief op literatuur en cultuur. Elk programma biedt veel ruimte voor individuele keuzes.

Het masterprogramma van Arts and Culture aan de Universiteit Leiden heeft een unieke positie op de kruising tussen kunstgeschiedenis en museologie. Door middel van toonaangevend interdisciplinair onderzoek geeft deze opleiding een sterke academische basis voor een verscheidenheid aan carrières in musea,…

Het masterprogramma van Arts and Culture aan de Universiteit Leiden heeft een unieke positie op de kruising tussen kunstgeschiedenis en museologie. Door middel van toonaangevend interdisciplinair onderzoek geeft deze opleiding een sterke academische basis voor een verscheidenheid aan carrières in musea,…

Hifadhi ya Dijiti ya Ustadh Mau

Als we een tekst lezen denken we te weten wie hem geschreven heeft, maar in de vroegmoderne periode was de productie van manuscripten vaak een gezamenlijke of 'gesocialiseerde' onderneming met secretarissen en schrijvers die fysiek schreven wat de auteur dicteerde.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: H.V.J. Linnartz

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: Prof.dr. B. van de Water

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotor: P.M. Brakefield

Doorstroomprogramma speciaal voor tweedegraadsbevoegde docenten Duits.

Doorstroomprogramma speciaal voor tweedegraadsbevoegde docenten Engels.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

De vakken die het VVI aanbiedt zijn onderdeel van het bredere onderwijsprogramma van de Faculteit der Rechtsgeleerdheid, dat programma’s aanbiedt op bachelor- (LLB) en masterniveau (LLM, Advanced Studies, PhD). Het instituut geeft een in Europa uniek MSc programma Law and Society: Governance and Global…

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger