There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: Prof.dr. W.T.F. den Hollander

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

In the first part of this thesis we study the geometry of folding patterns.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

In this thesis,

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Promotor: J. Zaanen

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Papyri in de klas

Van alle vormen van etnisch en raciaal vooroordeel heeft het antisemitisme verreweg de langste geschiedenis. In zijn nieuwe boek analyseert Chris Quispel het anti-semitisme over vijfentwintig eeuwen.

Het Leiden Institute for Area Studies (LIAS) doet interdisciplinair onderzoek naar Azië en het Midden-Oosten, van de oudheid tot nu.

Op woensdag 22 oktober hield de Faculteit der Archeologie open huis. Iedereen kon langskomen voor gratis lezingen, workshops met archeologisch materiaal. Je kon ook je eigen gevonden spullen meenemen om ze door een expert te laten bekijken.

Overzicht van de belangrijkste papyrologische websites

Wat betekent het om “gerechtigheid te brengen” in een overgangsperiode? Gerechtigheid voor wat, gerechtigheid voor wie, en met welk doel?

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…