The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Ontwikkelingen om de mariene biodiversiteit met hoge resolutie te meten, door ernaar te luisteren.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In het kader van de Honours Course ‘Crises in Biology’ die plaatsvond van 19 augustus t/m 2 september 2012 in Normandië, bezochten studenten vele geologische interessante locaties. Een van deze bijzondere plekken was de kust van Arromanches. Hier bemachtigden zij een enorm grote ammoniet die ze dinsdag…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

This thesis introduces the concept of

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

‘Legitimacy and Justice’ is een onderzoekscluster binnen het programma ‘Institutions, Decisions and Collective Behaviour’. De wetenschappers die hierin actief zijn houden zich bezig met de legitimiteit en rechtvaardigheid van politieke instituties. Zij kijken in het bijzonder naar de relaties tussen…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Je promotieonderzoek uitleggen aan anderen kan best lastig zijn, zeker zonder te praten! Promovendus Annebelle Kok van het Instituut voor Biologie Leiden stond in de finale van de ‘Dance Your PhD’-wedstrijd van wetenschappelijk tijdschrift Science. ‘Je moet je eigen onderzoek goed begrijpen, wil je…

Promotor: Prof.dr. H.L.V. Linnartz

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Om de klimaatcrisis het hoofd te bieden, kan een bepaalde nederigheid van de mens ten aanzien van de natuur van groot belang zijn. Tegelijkertijd kan nederigheid ook politieke overheersing in de hand werken. Hoe kunnen mensen zich op een bescheidener manier tot de natuur verhouden zonder hun vrijheid…

In Haagse jaren laat Theo Brinkel, bijzonder hoogleraar militair-maatschappelijke studies aan de Universiteit Leiden, Ruud Lubbers aan het woord. Brinkel interviewde de CDA-topman en oud-premier tussen 1992 en 1995 over zijn belevenissen aan het Binnenhof en in het torentje. In de lange gesprekken maakte…

Dit project bestudeert sociale afstand - de mate van begrip tussen mensen - in relatie tot het buitenlands beleid van staten. Geeft sociale afstand vorm aan politieke vooroordelen, hulpverhalen en, uiteindelijk, de prioriteiten en beslissingen van het buitenlands beleid van een staat?

Gaat de toenemende deelname van vrouwen aan verkiezingen in ruraal India het bestuur verbeteren?

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.