Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP) in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of Western…

Dit doctoraatsproject onderzoekt voornamelijk op welke manier (d.w.z. serieel, parallel of op een andere manier) de parser het Mandarijn-Chinees verwerkt. Daarnaast wordt onderzocht of er specifieke taalkundige kenmerken zijn die de decodering van het Mandarijn-Chinees bepalen en die verschillen van…

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

AI wordt veel gebruikt in HR-processen, maar we weten nog weinig over de bijdrage van deze applicaties aan eerlijke en inclusieve beslissingen. Leids onderzoeker Carlotta Rigotti is betrokken bij BIAS, een groot consortiumonderzoeksproject om de rol van AI te verduidelijken én een nieuwe app voor HR-professionals…

Promotor: Prof.dr. H.S. Overkleeft

Promotor: E. Bouwman, Co-promotor: S. Bonnet

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Promotor: Prof.dr. M.A.G.J. Orrit

Promotor: M.A.G.J. Orrit

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

De Una Europa Clusters brengen vooraanstaande deskundigen en ervaren personeelsleden van de talrijke academische en professionele diensten van de Una Europa -partners samen.

Discover the master program Health, Ageing and Scoiety at Leiden University and contribute to a future proof health care system. Read more.

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Onze medewerkers en studenten maken deel uit van de taskforces van Una Europa. Deze taskforces vertalen de kernthema’s van Una Europa naar concrete acties.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

Het Empower your PhD-project is een universiteitsbreed project, geïnitieerd vanuit de Faculteit der Sociale Wetenschappen (FSW)

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Drie onderzoekers van de Faculteit der Wiskunde en Natuurwetenschappen ontvangen een TOP-subsidie Exacte Wetenschappen. Dat maakte NWO op 22 november bekend.

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Deze cursus is ontwikkeld voor ervaren professionals met oog voor het publieke belang.

This dissertation explores how Large Language Models (LLMs) can effectively and responsibly contribute to complex decision-making processes. By combining AI and human intelligence, Hybrid Intelligence (HI) emerges, allowing the strengths of both humans and machines to be utilized.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Deze masterclass wordt gegeven door:

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Lezing, Com(parative) Syn(tax) Series

Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.

Vaak wordt gezegd dat een crisis iemands ware aard naar boven brengt. Het coronavirus stelt het multilaterale systeem op de proef. Politicoloog Gisela Hirschmann (Universiteit Leiden) maakt zich zorgen over de toekomst van internationale samenwerking.