Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

One-size-fits-all digital gamification sometimes hinders students’ learning due to the ignorance of individual differences. This project aims to explore how tailored digital gamification can be used in higher education and its effects on university students’ motivation and learning outcomes.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

The applications of studying the early development of insects range from agriculture to material science.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Source: Mediators Inflamm (2014)

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

The Dutch Advisory Committee on Public International Law has, on its own initiative, provided advice to the Dutch government regarding the duty of third states to prevent genocide under the Genocide Convention. The Committe's advice addresses the legal uncertainty in political and societal debates about…

How did changes in the composition and exploitation of princely domains in various principalities of the Low Countries influence the development of ‘modern’ public finance systems, including the notion of public debt?

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?

Scientists of the faculty of Governance and Global Affairs research completely different subject, among which terrorism, cybercrime and migration. In the upcoming weeks we will give the floor to several of our very best researchers. In this episode: migration researcher Alexandre Afonso.

China is conducting joint military exercises this week with Cambodia, Laos, Malaysia, Thailand, and Vietnam. In doing so, it is seeking to strengthen military ties with the ASEAN Member States amidst growing US presence in the region.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Following in the footsteps of Professor Jan Zaanen, visiting fellow Louk Rademaker is exploring quantum effects in so-called strange materials. His research is paving the way for new materials that could be used in emerging technologies.

Promotores: A.H. Meijer, H.P. Spaink

Promotor: B. van de Water

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Discovery of metastasis promoting candidate drug targets

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

The overlapping of intergovernmental organizations sharing Member States is one of the key challenges for achieving effective regional integration.

Following an investigation into plagiarism, Erasmus University Rotterdam has declared the master’s thesis of Dutch State Secretary for Long-term and Social Care, Vicky Maeijer, invalid. Wim Voermans, Professor of Constitutional Law, spoke to Dutch newspaper ‘Trouw’ about the matter.

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

‘Quantum technology is going to change the world, but most people don’t feel connected to it. I want to change that,’ says Julia Cramer, assistant professor at Leiden University. Known for her passion for science communication, Cramer actively seeks opportunities to share the wonders of quantum technology…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

On 7 and 8 July 2016 the T.M.C. Asser Instituut and the Law Faculty of Leiden University organise a two-day symposium on EPPO.

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

On 5 June, Maarten Aalbers defended the thesis 'The balancing of general interests in EU State Aid Law: blurred lines between the prohibition and the compatibility of aid'. The doctoral research was supervised by Pieter van Cleynenbreugel and Stefaan van den Bogaert.

A growing amount of literature is being devoted to interrogating gendered dynamics in both violent extremism and terrorism, contributing to the integration of international and feminist security. This includes how such dynamics can shape differences in the motivations and participation of women and…

In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.

Watching and analysing hundreds of TEDx talks, that too can be research. That becomes clear from the work of PhD student Aletta Meinsma, who is studying potential problems in popular communication about quantum technologies. She explains how she approaches this and why it is so important.

The Hague Diplomacy Podcast aims at bringing the themes of the journal's research off the page, and onto the discussion table. Each episode will feature a guest who will share their insights and personal experience within their practice of or research on diplomacy. Available via SoundCloud, Apple Podcasts…

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Computer says no: end of story. Twenty years ago, a hilarious line in the British TV series Little Britain, now a reality. We all blindly follow technology at times, with varying consequences. For ISGA lecturer and researcher Daan Weggemans, it's a subject worthy of a PhD.

Getting personal

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

Eduard Fosch-Villaronga, Associate Professor at eLaw, presented his work on ‘Aligning rules and actions in digital innovation’ at the conference on Technology and Sustainable Development, This event explored whether technology can be used to fix the very problems caused by technology, encompassing social,…