Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Investigating the emergence of complex societies in Chalcolithic Cyprus.

Making sensitive data reusable through synthetic data generation

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

Tumours act like mini-organs, manipulating their environment and using bodily processes to survive and metastasise. Through research by Erik Danen and his colleagues, we are learning more about the complex nature of tumour cells. In the Dutch newspaper NRC, the scientists discuss their findings.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, explore our standout discoveries and most inspiring collaborations from the past year!

Factors affecting galanthamine production in Narcissus

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

Division contact information & address

With a perspective-based approach to education, students' knowledge, skills and attitude are linked.

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The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.

How does global change across time and space lead to convergence and loss of variation or increasing diversity and conflict?

The goal of this book is to place architectural studies, in which people’s interactions with each other and material resources are key, at the crossing of both landscape studies and material culture studies, where it belongs.

Didactics

This research programme seeks to understand the dynamics in the relationship between social media, mobile telephony and the social fabric under duress in Africa's mobile margins. It combines studies on mobility/migration, conflict and communication in an attempt to uncover these new dynamics, which…

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This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

The Directorate-General Police, Sanctions, and Protection has initiated this research project in order to gain insight in the nature and, if possible, the extent of the developments with regards to the pluralization of policing functions in the Netherlands in support of future policies for the benefit…

Who were the main artists and producers who generated new forms of popular music? What was the music like that was produced by artists in particular urban settings? How were particular lifestyles articulated to identify new audiences and what does this reveal about the way popular music contributed…

Criminal Justice as a concept refers to the system of practices and institutions of governments directed at upholding social control, deterring and mitigating crime, or sanctioning those who violate laws with criminal penalties and rehabilitation efforts. While the definition seems rather clear-cut,…

This is an Erasmus+ International Credit Mobility project of Leiden University with the American University in Cairo.

From applied to fundamental research, and from algebra to data science, our master’s programme spans these fields entirely. You will be able to follow courses from the national Mastermath programme and write a thesis in one of our strong research groups in algebra, number theory and geometry; dynamical…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Key publications of the Cancer Drug Target Discovery group

Supervisor: Andrea Martella

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Master projects are available in

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: E. Bouwman, Co-promotor: S. Bonnet

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.