This lecture will be hosted on Thursday, 6 November 2025 at 6:00 pm.

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Joris Larik, Assistant Professor at Leiden University, wrote about the topics of the Brexit, the EU-UK Withdrawal Agreement, and Global Treaty (Re-)Negotiations.

The Explainatory Data Analysis group develops algorithms and theory that enable domain experts to explain data by finding interpretable patterns and models.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

The first book ever on information-theoretically secure multiparty computation

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Promotor: Prof.dr. G.P. van Wezel

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Western thought has often dismissed shadows as fictional, but what if fictions reveal original truths?

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

On 28 June, Jakob Tobing defended the thesis 'The essence of the 1999-2002 constitutional reform in Indonesia: remaking the Negara Hukum. A socio-legal study'. The doctoral research was supervised by Jan Michiel Otto and Adriaan Bedner.

This book presents a thorough analysis of the Kurdistan Region of Iraq’s memory culture, focusing particularly on commemorations and representations of the Anfal and Halabja atrocities.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Sociopragmatics is a rapidly growing field and this is the first ever handbook dedicated to this exciting area of study.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Prof.dr. E.J.J. Groenen

EU foreign policy has become increasingly politicised over the past years, amongst others as a consequence of the succession of crises. Crises may engender processes of crisis framing and contestation. This article focuses on how the policy demands being voiced in these processes of contestation are…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This research develops and applies a new approach to study Aegyptiaca Romana from a bottom-up, Roman perspective.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This book offers novel perspectives on the national and international dimensions of the post-war welfare state in Western Europe and North America.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

On this page the programme and sessions can be found.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

These podcast episodes were written for the Green Office’s Spring Podcast competition and miniseries 'Beyond the Safe Space', on the theme: the Planetary Boundaries, which took place between the months of March-May 2023.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Lecture

PhD defence