Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Today’s performances of medieval polyphony have a lot in common with those of other ‘classical’ or ‘early’ music. Ensembles perform pieces written by known or lesser known composers, which the listener can revisit by listening to recordings or reading a score.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

This book explores the relationship between the production of new urban spaces and illiberal community-making in contemporary India. It is based on an ethnographic study in Noida, a city at the eastern fringe of the state of Uttar Pradesh, bordering national capital Delhi.

From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…

The need for knowledge among practitioners and the lack of an academic knowledge base for specifically collective arrangements of social work in the Netherlands were the reason for Anouk de Koning, Femke Kaulingfreks and Maartje van der Woude to start working on a Dutch Research Agenda (NWA) application…

Have you ever wondered what makes immigrants legally different no matter which legal system they have moved into and no matter what rights have been granted there? Have you ever wondered why immigrants are considered ‘the other’ despite claims that their ‘integration’ and non-discrimination is a top…

Staging the Archive: Art and Photography in the Age of New Media is dedicated to art practices that mobilize the model of the archive, demonstrating the ways in which such archival artworks probe the possibilities of what art is and what it can do.

In February 2014, the Swiss voting population accepted a constitutional initiative that aims at limiting migration through quota and, in the field of employment, national preference.

This book explores the reception of foreign news during the late sixteenth-century civil wars in France and the Netherlands.

A 5 million euros grant from the Dutch Research Agenda allows Anouk de Koning and co-applicants Femke Kaulingfreks and Maartje van der Woude to study social interventions in eight Dutch cities in an innovative and interdisciplinary way.

Understanding the evolving landscape of extremism in the 21st century.

The Institute of Security and Global Affairs (ISGA) hosts two research journals and publishes the ISGA Reports series. Besides its own publications, researchers at ISGA also publish books or journal articles elsewhere. You can find all these external publications under Research output on the right.

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

Universiteiten moeten niet verbaasd zijn dat studenten ChatGPT gebruiken, schrijven de Leidse universitair docenten Femke Klaver en Alexander de Wit in Trouw. Want studenten reageren op efficiëntie en doelmatigheid. Hun suggestie: Leid studenten op om kritisch na te denken.

Television presenter and journalist Twan Huys will be a lecturer in Journalism and New Media at Leiden University from 1 September 2024.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This book brings together a collection of emergent research that moves the debate on desistance beyond a general consideration of individual and social structural influences.

In this book, a new generation of scholars offers fresh perspectives on the history of the Dutch slave trade. Traditionally, Dutch research has focused on business practices, often overlooking the enslaved and the complexities of illegal trade and violence.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Following the terrorist attacks in Paris (November 2015) and Brussels (March 2016), Belgium’s counterterrorism policy has been heavily criticized – domestically and worldwide.

In this study, Bibi van den Berg and Sanneke Kuipers from ISGA, explore the ways in which cyber-related incidents may lead to crises

Currently the focus of the project is the development of a tool that utilizes dimensionality reduction techniques in order to analyze and interpret the lexical and phonological variation between different sign languages. Additionally, the application of deep learning techniques for the extraction of…

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The book offers different theoretical perspectives to help examine the process of public sector reform. In addition it gives an overview of the major trends in the core areas of the functioning of the public sector.

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Nikki Ikani, Assistant Professor Intelligence and Security at the Institute of Security and Global Affairs (ISGA), has recently published her latest monograph 'Crisis and change in European Union foreign policy' with Manchester University Press.

In what ways does Atelier education contribute to skills development, active learning, interactions between students and staff, and connections between disciplines of law?

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

Prof. Mark Leiser and a team of thirteen law students from Leiden University’s Advanced LLM programmes in European and International Human Rights Law as well as in Law and Digital Technologies together drafted a report for the UN Special Rapporteur on the Promotion and Protection of the Right to Freedom…

The Mathematical Institute has a rather liberal management structure. Tasks and responsibilities are distributed among the staff. Important decisions are taken by consensus. Various organisational divisions are featured below.

At the Faculty of Archaeology, we investigate the development of human societies worldwide, from the earliest beginnings to modern times. We also study the heritage of mankind, which evokes this deep history, and which connects with, and informs, contemporary society.

Is the legitimacy of law and governance of multilevel jurisdictions diminishing? What is the significance of (diminishing) legitimacy for the effectiveness of law? These kinds of questions about the legitimacy of the supranational formation of law, its application, and the policy and governance based…

The Dutch Student Orchestra (NSO) brings together more than a hundred of the best student musicians in the Netherlands. On 16 February the NSO will be performing in Leiden. Two Leiden members of the orchestra give a foretaste of the concert.

What impact does ethnic profiling and accusations of ethnic profiling have on organizations and the border police officers working at the operational level, and what structural factors on the societal and organizational level contribute to the process of ethnic profiling? Over a period of three years…

On 3 and 4 March, the 2nd Doctoral Seminar on International Criminal Law, International Human Rights Law and International Humanitarian Law was held at the Siracusa International Institute for Criminal Justice and Human Rights in Sicily. Ida Asscher and Anna Smulders, both PhD Candidates at the Grotius…

Fake news a new phenomenon? Not according to Rens Tacoma and Indira Huliselan. In an NWO project, the associate professor and PhD student will delve into the twisting, scheming and tampering with facts that went on thousands of years ago.

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.