Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…

Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

Sjaak Neefjes, Professor of Chemical Immunology at Leiden University, will receive the NWO Spinoza Prize this year. The Spinoza Committee called Neefjes an ‘exceptional researcher whose intelligence is matched by his boldness’. He will use the 2.5 million euro prize to pursue his research into cancer…

The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

Leiden astronomers and ecologists are developing an instrument that lets people measure the quality of surface water with a smartphone.This international citizen science project, MONOCLE, is a collaboration between scientists and local people in Tanzania, Brazil and four European countries.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

To what extent are, can, and should, human trafficking and human smuggling be(ing) seen as interlinked phenomena? What are the consequences of seeing the phenomena as either distinct or interlinked for the way in which migrants crossing intra-Schengen borders are treated.

Heart failure is a major health care problem with high mortality.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Democracy in Action (DiA) is a Horizon Europe-funded initiative exploring how grassroots movements, cultural spaces, and digital innovations can strengthen democratic participation. With a special focus on youth, women, ethnic minorities and night culture, we bring together researchers, grassroots movements,…

A team led by Erik Danen from the Leiden Academic Centre for Drug Research has received a 3 million euros NWO Science Groot grant to unravel the first steps of metastasis. Danen will work together with biologists and theoretical and experimental physicists from Dutch Universities. ‘Understanding these…

Sander van Kasteren only noticed some small, subtle changes since he was appointed professor on 1 May. Still, he has to get used to the idea, even though he had been working towards the professorship for a few years. ‘I don't quite see myself as a professor yet.'

How are night spaces imagined, produced, experienced and narrated by migrant communities in Europe? This research project considers this question in eight European cities: Aarhus, Amsterdam, Berlin, Cork, Galway, Lisbon, London, Rotterdam. Authorities have historically wrestled with the issue of night-time…

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The Dutch Center for Travel Writing Studies s a scientific center that develops and coordinates initiatives to promote research into travel writing. It actively seeks contact with external (scientific and social) partners to collaborate on issues surrounding cultural / national identity, cultural contact…

Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.

This is an Erasmus+ International Credit Mobility project of Leiden University (university wide) with Al-Quds University in Palestine.

Promotor: Prof.dr. T. Schmidt

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.