The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Cardiovascular disease is the leading cause of death worldwide.

Promotor: J. Schaye

In this doctoral dissertation (2012) the effects of the monetization of the Greek world in the 5th and 4th century on conceptions of reciprocity in friendship are analyzed.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Facts, Fears and the Future of Islamic Rules on Family Relation in the West

Consensus and harmony or balance and reciprocity?

Promotor: H.V.J. Linnartz

This third issue of Ex Novo gathers multidisciplinary contributions addressing mobility to understand patterns of change and continuity in past worlds; reconsider the movement of people, objects, and ideas alongside mobile epistemologies, such as intellectual, scholarly or educative traditions, rituals,…

On 22 February, Elody Hutten defended the thesis 'Tax Professionals Under Societal Pressure: A Dutch Case Study on Responses to BEPS'. The doctoral research was supervised by Henk Vording en Jan Vleggeert.

In this article, Tokdemir & Klein examine the strategic actions of governments against domestic terrorist groups and domestic terrorist groups’ reactions to such actions.

This thesis describes the design, characterization and application of dextran based crosslinked network.

What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Several alumni, young alumni and students have been matched via the Leiden University Mentor Network.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Terrorism destabilizes governments, undermines civil society, threatens social and economic development, endangers democracy, and directly impacts human rights. The extraordinary events on 9/11 turned counterterrorism into a global governance project. The global collaboration is unprecedented with traditional…

Promotor: Prof.dr. H.L.V. Linnartz

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Observational, cognitive and physiological measurements in social contexts.

Eschatology played a central role in both politics and society throughout the early modern period. It inspired people to strive for social and political change, including sometimes by violent means, and prompted in return strong reactions against their religious activism.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Research at the BPOC/SSNMR group is comprised of the following research themes:

Three research projects with researchers from Leiden University have received a Dutch Research Council Open Competition Science-M grant. This is for innovative, high-quality fundamental research within the science domain.

Which molecules go into forming planets? PhD candidate Christian Eistrup and his colleagues have created new models to research this question. Their findings could change our idea of which molecules were forming Jupiter or even Earth.

How can we supply the growing world population with sustainable energy? At Laurens College in Rotterdam, Prof. Marc Koper speaks with the students about the crucial role of chemistry in the energy transition. Guest classes like this are a good way for school students to learn about the academic world,…

The Gouy-Chapman theory describes what happens near an electrode when it is in contact with a salt solution, but this description does not match reality. Researcher Kasinath Ojha, assistant professor Katharina Doblhoff-Dier and professor Marc Koper present a new version. ‘The next generation of textbooks…

The surface of platinum electrodes changes much more during use than was previously thought. In a collaboration between the Leiden Institutes of Chemistry and Physics, chemists Leon Jacobse, Yi-Fan Huang and Marc Koper, and physicist Marcel Rost have been able to show this for the first time. Publication…

Lecture

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

The electrochemical reduction of a group of organic compounds on platinum is strongly dependent on the arrangement of the atoms in the platinum surface. Christoph Bondue, postdoc in Marc Koper's group, published this in Nature Catalysis on 4 March. The reduction of such compounds is an important process…

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

How do different emotional expressions influence the behavior of other people in negotiations?

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

On 5 September 2017, Alessandro Tonutti defended his PhD dissertation

On this page, you can find video's explaining the research of LUCAS members.

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.