This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Abstract submission is now open for the international conference of the ELS Academy, in Amsterdam on September 1 and 2.

Tijdens een feestelijke virtuele bijeenkomst op 8 december werd Cisca Hoogendijk ter gelegenheid van haar 65ste verjaardag verrast met een feestbundel, met als editors haar oud-studenten aan het Leids Papyrologisch Instituut Joanne Stolk (Gent/Oslo) en Guus van Loon (Wenen).

The Gennadius Library of the American School of Classical Studies at Athens announces the summer session focused on the study of Medieval Greek, from June 26 to July 27, 2023. The Library invites applications for a month-long Summer Session for Medieval Greek at the Intermediate to Advanced Level. The…

142 studenten van de nieuwe bacheloropleiding International Studies van de Universiteit Leiden ontvangen op 28 augustus hun diploma. Ze hebben hun opleiding in drie jaar afgerond.

Promotor: H.J.M. de Groot

Kunst en vrije tijd, Kunst en vrije tijd

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: Prof.dr. L.J. Slikkerveer

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Sinds kort bestaat het Leiden University Buddhist Studies Network, opgericht bij het LIAS, het Leiden University Institute for Area Studies.

Studievoorlichting

Promotie

From 3 to 5 September 2025, the project Governing and Building the City will organize the conference 'Good Governance and the Built Environment of Late Medieval Cities (ca. 1200–1600)' at KBR in Brussels. The deadline for the call for papers is 7 April.

Het was 14 oktober weer een drukte van jewelste in de zonovergoten binnenstad van Leiden. Enkele duizenden scholieren en hun ouders bezochten de Open Dag. Bij de informatiemarkt in de Pieterskerk spraken we enkele studiekiezers met elk hun eigen vragen, twijfels en overwegingen.

Lezing, Tuesday Talks: Science Insights

Stage lopen bij de Politieacademie in Apeldoorn. Dat kan vanaf september 2021 voor het eerst voor derdejaarsstudenten van het bachelorprogramma Security Studies nu de Universiteit Leiden en de Politieacademie de handen ineen hebben geslagen. ‘De stageplaatsen bieden studenten een unieke kans op een…

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Radboud Ancient and Medieval Studies organiseert ook dit jaar een lezingenreeks. Het programma voor het eerste semester is hieronder te vinden.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.