This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: J. Aarts

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Control of infectious diseases poses continuous challenges for human health.

Klinische psychologie richt zich vooral op de toepassing van wetenschappelijke psychologische kennis op assessment, preventie en behandeling van psychopathologie.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Promotor: C.J. ten Cate

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Promotor: H.V.J. Linnartz

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Het gebruik van ‘Big data’ is niet meer weg te denken binnen het wetenschappelijk onderzoek. Voor dit onderzoek maken we gebruiken van diverse grote databestanden.

Promotores: G.W. Canters, T.J. Aartsma

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotor: Prof.dr. M.L. van Hecke

Promotor: J. Zaanen

Van oudsher werden donder en bliksem gezien als Gods strafwerktuigen. De uitvinding van de bliksemafleider door Benjamin Franklin in 1752 bracht hierin echter verandering. Welke gevolgen hadden de uitvinding en invoering van de bliksemafleider voor de manier waarop men aankeek tegen het onweer? Jan…

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.