452 zoekresultaten voor “individual verschillende” in de Publieke website
-
High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
-
Soil legacy effects on aboveground plant-insect interactions
In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.
-
Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
-
Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
-
Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
-
Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
-
Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
-
Non-equilibrium chemistry and cooling in simulations of galaxy formation
Promotor: J. Schaye
-
Robust rules for prediction and description.
In this work, we attempt to answer the question:
-
Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
-
Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…
-
Faith in Democracy. Justice, Politics and Transcendence
This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.
-
Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
-
The urge to collect
Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?
-
Custom-made online language courses
Make use of this time to improve your language skills by signing up for custom-made online language classes.
-
Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
-
Environmental footprints: assessing anthropogenic effects on the planet's environment
Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs
-
The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
-
From atoms to the cosmos: exploring the cosmic web beyond collisional ionisation equilibrium
Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…
-
Aspects of Record Linkage
Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft
-
Innovation and stasis
The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.
-
The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
-
High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
-
Through the magnifying glass
Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.
-
Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
-
Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
-
North Sea noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
-
RAISE Onderzoek
Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…
-
Study Information Committee
The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…
-
Mechanical Response of Foams: Elasticity, Plasticity, and Rearrangements
Promotor: M.L. van Hecke
-
Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
-
Towards a Relational Approach to Understanding Interactions in Interactive Art
This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.
-
Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
-
An Algebra for Interaction of Cyber-Physical Components
Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.
-
The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
-
Diversity in the globally intertwined giant barrel sponge species complex
This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.
-
Geometry and Topology in Active and Driven Systems
The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).
-
Opinion Dynamics on Random Graphs
This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.
-
Man-vrouw verschillen in mentale gezondheid
Bekend is dat autisme en ADHD vaker voorkomen bij mannen, en een depressie of angststoornis vaker bij vrouwen. Toch is nog steeds de invloed niet duidelijk van geslachtsverschillen op mentale gezondheid. Daarom organiseerde Lara Wierenga samen met Marieke Bos een vijfdaagse Lorentz-workshop met 25 internationale…
-
Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
-
Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
-
Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
-
De Koreaanse golf
De onstuitbare opmars van de N.V. Zuid-Korea
-
Onderwijs
Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.
-
SCS Courses
The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.
-
Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
-
Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
-
Het monotheïstisch dilemma: theologie van het terrorisme
In Het monotheïstisch dilemma: theologie van het terrorisme (2010) gaat het om de relatie tussen religie en geweld.
-
Nanoparticles and Microfluidics for Future Tuberculosis Vaccines
Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.
-
Strategy Dynamics
In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.