This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotor: Prof.dr. J. den Hertog

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs doet onderzoek naar stagnaties die kunnen optreden in de cognitieve ontwikkeling.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Promotor: A. Kros

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: B.van de Water, Co-promotor: L.S.Price

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotores: G.W. Canters, T.J. Aartsma

Promotor: H.V.J. Linnartz

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

Migratie is van alle tijden. Toen de Verenigde Staten werd ‘herontdekt’, trokken veel mensen daar naartoe. Ook Nederland koloniseerde een deel van Amerika en gaf het de naam Nieuw-Nederland. Masterstudent Geschiedenis Pepijn Doornenbal doet onderzoek in de VS naar hoe er in Nieuw-Nederland werd omgegaan…

Promotie

Cursus

Zwolse agenten rukten uit voor de aanranding van een minderjarig meisje. Berichten hierover werden door de politie via Instagram Stories gedeeld. Op een van die berichten was een foto te zien van een mutatierapport, waarop de naam van het slachtoffer en de locatie van de aanranding niet goed waren w…

Jongeren besteden heel veel van hun tijd online. Toch weten we nog weinig over hoe dit intensieve (sociale) mediagebruik hun ontwikkeling beïnvloedt. Hersenonderzoeker en Spinozapremie-winnaar Eveline Crone van de Universiteit Leiden beschreef samen met mediapsycholoog Elly Konijn (VU) wat de wetenschap…

De gemeente Amsterdam heeft veel last van groepen hangjongeren. Om dit aan te pakken, werden de Facebook-gegevens van deze jongeren verzameld en geanalyseerd.

Het lijkt er steeds meer op dat Elon Musk in z'n eentje bepaalt wat er wel of niet op Twitter mag worden gezegd. Hij kocht het platform met de boodschap dat er alle ruimte moet worden geboden om te kunnen zeggen wat je wil, maar dat uitgangspunt brengt hij nu zelf aan het wankelen.

Lezing, Faculty Lecture

Promotie

Promovendus Vincent Koeman wil dat echt iedereen met quantum in aanraking komt. Hoe hij dat doet? Met een quantum pop-up tentoonstelling in de lokale bibliotheek én op Lowlands Science. Hij vertelt erover in het Leidsch Dagblad en New Scientist.

Wetenschapper Eveline Crone zet zich samen met astronaut André Kuipers en kunstenaar Daan Roosegaarde in voor het Weekend van de Wetenschap op zaterdag 6 en zondag 7 oktober 2018. De drie ambassadeurs zijn op diverse locaties aanwezig om het publiek kennis te laten maken met de innovatieve en nieuwsgierig…