Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…

Promotor: J. Schaye

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Voor goed onderzoek is het nodig om buiten de grenzen van vakdisciplines te kijken, stelt hoogleraar moleculaire en cellulaire biochemie Remus Dame in zijn oratie op 10 mei. Zo zouden processen die plaatsvinden op DNA niet alleen moeten worden onderzocht in een reageerbuis maar ook in levende cellen…

Geen proefjes en labjassen, maar computers en kunstmatige intelligentie: dit jaar ging de Nobelprijs voor de Scheikunde naar de bedenkers van het baanbrekende AI-model Alphafold. Dit programma voorspelt met indrukwekkende nauwkeurigheid eiwitstructuren aan de hand van hun genetische code. Dat is cruciaal…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

During the course of drug discovery translational steps are made.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: Prof.dr. M. Ubbink

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Check hieronder de aanmelddeadlines voor de opleiding Molecular Science and Technology.

Promotie

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

We consider the propagation of electrical signals through nerve fibres.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Fundamental research in the ALgebra, Geometry And Number Theory

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.