Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotor: J. Zaanen

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Promotor: Prof.dr. D. Bouwmeester

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

Promotor: Prof.dr. M. Ubbink

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

In this thesis integral points on affine del Pezzo surfaces are studied.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. J.W.M. Frenken

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Computers worden steeds krachtiger en krijgen steeds ingewikkelder taken. Het Leiden Institute of Advanced Computer Science (LIACS) doet baanbrekend wetenschappelijk onderzoek en past nieuwe vindingen toe in actuele maatschappelijke vraagstukken.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: A.P. IJzerman

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: A.P. IJzerman

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

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