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673 zoekresultaten voor “stam cell differentiatie” in de Publieke website

• Getting personal: Advancing personalized oncology through computational analysis of membrane proteins Onderzoeksoutput

  Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

• The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine Onderzoeksoutput

  G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

• Synthesis of chemical tools to study the immune system Onderzoeksoutput

  This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

• Cholesterol metabolism and hematopoiesis interaction in atherothrombosis Onderzoeksoutput

  Cardiovascular disease is the leading cause of death worldwide.

• Uncovering vulnerabilities in triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

• Towards a mechanistic understanding of nanoparticle behavior using zebrafish Onderzoeksoutput

  The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

• Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana Onderzoeksoutput

  Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

• Synthesis of Ribitol Phosphate based Wall Teichoic acids Onderzoeksoutput

  Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

• Systems vaccinology: molecular signatures of immunity to Bordetella pertussis Onderzoeksoutput

  Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

• Dynamics and regulation of the oxidative stress response upon chemical exposure Onderzoeksoutput

  The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

• The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus Onderzoeksoutput

  Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

• Disrupting the transcriptional machinery to combat triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

• The advantages and disadvantages of bioorthogonal proteins Onderzoeksoutput

  This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

• Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer Onderzoeksoutput

  This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

• Design, synthesis and application of paramagnetic probes for protein structure studies Onderzoeksoutput

  The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

• Exploring novel regulators and enzymes in salicylic acid-mediated plant defense Onderzoeksoutput

  Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

• Nieuwe antibiotica Wetenschapsdossier: Samenwerken voor efficiënte medicijnontwikkeling

  Ziekteverwekkende bacteriën zijn steeds vaker resistent voor de huidige antibiotica. De vraag naar nieuwe antibiotica wordt daarmee steeds groter. Professor Gilles van Wezel zoekt naar nieuwe vormen van antibiotica in goede bacteriën die in de grond leven.

• Van alef naar alfa: de verspreiding en ontwikkeling van het alfabetisch schrift rond de Middellandse Zee Onderzoeksproject

  Wanneer en hoe werd het alfabetisch schrift geïntroduceerd in Griekenland en andere delen van het Middellandse Zeegebied?

• T-cell gene therapy for low mutational burden cancer Agenda - 9 januari 2025

  Promotie

• 
  Cecile Herbermann Project analist

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Ferdinand Teichert Promovendus / gast

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Nina Schulten Onderzoeksanalist

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Max Fernkorn Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Benjamin Tak Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Rafaella Buzatu Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Yuting Wang Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Andreea Iosif Analist

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Micha Drukker Hoogleraar

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Jingchao Wu Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Eliane Züger Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Ruben de Vries Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Yubin Guo Promovendus / gast

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Daan Vlemmings Analist

  Faculteit der Wiskunde en Natuurwetenschappen

• 
  Christian Schröter Universitair docent

  Faculteit der Wiskunde en Natuurwetenschappen

• Exploring big data approaches in the context of early stage clinical Onderzoeksoutput

  Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

• Activity-based protein profiling in drug discovery Onderzoeksoutput

  In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

• Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice Onderzoeksoutput

  In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

• Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana Onderzoeksoutput

  Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

• Developing systems for high-throughput screening of infectious diseases using zebrafish Onderzoeksoutput

  Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

• Microglial lipid metabolism: a delicate balance Onderzoeksoutput

  Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

• PLGA-based particulate vaccine delivery systems for immunotherapy of cancer Onderzoeksoutput

  Promotores: W. Jiskoot, F. Ossendorp

• CE-MS for metabolomics: advancing performance and detection sensitivity Onderzoeksoutput

  The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

• The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea Onderzoeksoutput

  Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

• Direct and two-step activity-based profiling of proteases and glycosidases Onderzoeksoutput

  Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

• Cancer chess: molecular insights into PARP inhibitor resistance Onderzoeksoutput

  The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

• Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management Onderzoeksoutput

  The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

• To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors Onderzoeksoutput

  Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

• Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor Onderzoeksoutput

  Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

• Allosteric modulation and ligand binding kinetics at the Kv11.1 channel Onderzoeksoutput

  Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman