Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Doorstroomprogramma speciaal voor tweedegraadsbevoegde docenten Frans.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

Kunst en vrije tijd, Kunst en vrije tijd

Vind jouw thuis bij LUC! Wij zijn gevestigd in het hart van Den Haag. Met ons eigen gebouw en internationale profiel biedt LUC een omgeving voor iedereen die op zoek is naar een interculturele ervaring en die een verantwoordelijke wereldburger wil worden.

Is dat appje bot of juist vriendelijke bedoeld? In geschreven taal ligt een misinterpretatie altijd op de loer. Universitair docent Lauren Fonteyn legt in Trouw uit hoe dit komt.

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

How can we broaden youth participation in STEM Learning

Workshop

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

The global agri-food system plays a critical role in food security and environmental issues.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…