In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

2020 is een jaar waarin we onszelf opnieuw moeten uitvinden, ook binnen de marketingafdeling van onze faculteit. Al jaren organiseren onze medewerkers kennismakingsactiviteiten zoals de Bachelor Open Dagen, Masterdagen en Proefstuderen. Vanaf maart moest alles anders.

Het Nederlands Studenten Orkest (NSO) verenigt ruim honderd van de beste student-musici van Nederland. Op 16 februari komt het orkest naar Leiden. Wij spraken met twee Leidse orkestleden en zij gaven direct een voorproefje van het concert.

Maandag jl. werden de Speckmann-prijzen uitgereikt voor het beste Bachelor leeronderzoeksverslag en de beste masterscriptie geschreven in het studiejaar 2011-2012.

Na vele jaren was het dan eindelijk zover. Het Leidse pleitteam (bestaande uit Anne van der Meeren, Heleen Kleinjans, Dries van de Voort, Sophie Vonk en Remco de Lijster en begeleiders Femke Binnendijk en Rogier Kegge) heeft de jaarlijkse pleitwedstrijd van de Vereniging voor Bestuursrecht (VAR) gew…

Zowel met spel als politiek kunnen werelden worden geschapen waarin nieuwe regels gelden, betekenissen worden gecreëerd en mogelijkheden ontstaan voor samenwerking, strategie en creatieve oplossingen. In die zin hebben spel en politiek altijd veel gemeen gehad. Maar wat gebeurt er met deze verwantschap…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Promotor: K.H. Kuijken

Promotor: Prof.dr. H.L.V. Linnartz

Gebruik en ontwikkel je talenten.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This thesis covers various applications of topology in condensed matter physics and quantum information.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Een historische blik achter de betonnen schermen van de Amerikaans-Nederlandse betrekkingen.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.