Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Promotor: K.H. Kuijken

Promotor: Prof.dr. H.L.V. Linnartz

Gebruik en ontwikkel je talenten.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This thesis covers various applications of topology in condensed matter physics and quantum information.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Een historische blik achter de betonnen schermen van de Amerikaans-Nederlandse betrekkingen.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

Kijk mee en praat mee over de wetenschap van het verleden tijdens wekelijkse Let’s Plays van populaire games en vodcasts op het livestreamplatform Twitch.

This thesis is about cosmological inflation and its relation to observations.

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

In 2009-2010 ontstond in het westerse discours het idee van een meer ‘assertief’ China, een opvatting die China krachtig van de hand wijst. Niettemin is, vooral sinds Xi Jinping in 2012 aan de macht kwam, duidelijk dat China zijn lang gehanteerde buitenlandse beleidsdoctrine van ‘een lage profilering…

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Promotor: W. Jiskoot, Co-promotor: A. Kros

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

Lezing

Maandag jl. werden de Speckmann-prijzen uitgereikt voor het beste Bachelor leeronderzoeksverslag en de beste masterscriptie geschreven in het studiejaar 2011-2012.

Na vele jaren was het dan eindelijk zover. Het Leidse pleitteam (bestaande uit Anne van der Meeren, Heleen Kleinjans, Dries van de Voort, Sophie Vonk en Remco de Lijster en begeleiders Femke Binnendijk en Rogier Kegge) heeft de jaarlijkse pleitwedstrijd van de Vereniging voor Bestuursrecht (VAR) gew…

Panel discussion

Promotie