Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: Prof.dr. B. van de Water

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: T. Schmidt

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Supervisor: P.J.J. Hooykaas

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotores: J. Jonkers, K.E. de Visser

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Prof.dr. B. van de Water

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Hoe kan wetenschap op een verantwoorde manier worden uitgevoerd, beoordeeld en aangestuurd? Het zijn vragen die ook de universiteit zelf van het grootste belang zijn. Het Centrum voor Wetenschaps- en Technologiestudies (CWTS) bestudeert wetenschappelijk onderzoek en zijn relatie met technologie, innovatie…

Algemene contactinformatie

Check de volgende toelatingseisen voordat jij je aanmeldt voor de opleiding Molecular Science and Technology.

Het Leiden Centre of Data Science (LCDS) is in Den Haag druk bezig met het ontwikkelen van een multidisciplinaire opleiding Legal Technologies in nauwe samenwerking met het Centre for Professional Learning (CPL). Zij werken hierbij samen met drie faculteiten van de Universiteit Leiden, namelijk de Faculteit…

Technologische ontwikkelingen gaan snel. Het Leiden Legal Technologies Programme stond op de agenda van de Adviescommissie tijdens de tweede bijeenkomst op 15 oktober. Het besluit om het programma in januari 2021 te starten is unaniem genomen. Het was het officiële moment om de afronding van de voorbereidingen…

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…

Congres/symposium, Lorentz Center workshop

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Den Haag is, naast Leiden, de tweede moederstad van de Universiteit Leiden.