This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Uncover novel antimicrobials with prospective health benefits for sea turtles.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Building a sustainable, international and interdisciplinary consortium for developing evidence-based communication strategies about Antimicrobial Resistance. That is the objective of a new project between researchers from Leiden University, VU Amsterdam and Stellenbosch University in South Africa, made…

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Professor Biological chemistry Nathaniel Martin from the Institute of Biology Leiden is interviewed by the Netherlands Innovation Network on innovative scientific approaches. He talks about his work on designing new antibiotics and developing new molecules to make resistant bacteria susceptible again…

January 1st 2017, Bastiaan Steffens will be taking up the Graduate Teaching Assistance PhD position at the Archaeology and Ancient History department at Leicester University.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Two consortia led by Leiden researchers have been awarded over one million euros by the Dutch Research Council and the Ministry of Health, Welfare and Sport to find solutions to antimicrobial resistance.

Optimised antibiotic combinations can combat bacteria more effectively while also slowing the development of resistance. Scientists from five European countries are joining forces to identify such combinations and provide tools for others to do the same. The project is led by Professor Coen van Hasselt…

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.

The Advisory Board consists of five eminent scientists with specialist expertise in complementary disciplines. They all have prominent positions in the field of Computer Science in the Netherlands outside our own institute.

An overview of Quantitative Pharmacology projects

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Key publications of the Antiviral Pharmacology group.

Promotor: Prof.dr. G.P. van Wezel

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

The sites of Norman Estata, Anse des Pères and Hope Estate with a contribution to the 'La Hueca problem'

The Private International Law Department provides academic education and performs research in the field of private international law.

The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The Kroese-Duijsters Symposia started in 2022 and we are pleased to invite you to the 4th Kroese-Duijsters…

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

Researchers at the Faculty of Science work every day at the frontiers of knowledge, tackling today’s major societal challenges. Their work is recognised through grants, prizes and other awards. We highlight some of these achievements.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

PhD defence