The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Raised by his grandmother and grandfather, trained as a doctor, the medical director of a camp for Eritrean refugees: Ephrem Tesfay was anything but a typical student when he arrived in Leiden in 2019. Still, he fit in well with the ‘youngsters’.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The research that is united in the Liveable Planet programme, touches upon a wide range of aspects of human life. The goal is to deepen and expand the scope and to connect more researchers. The following case studies are examples of current research projects.

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

A comprehensive analysis of Nietzsche's conception of conflict and the way in which relations of struggle condition the organisation of complex systems (with a specific focus on the human psyche and the body politic).

NimbleAI aims at solutions for ultra-energy efficient and secure neuromorphic sensing and processing at the edge.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

The central aims of MicroClock project are to describe the B. subtilis circadian clock at molecular and functional levels, and discover the mechanisms of clock-regulated bidirectional signaling between B. subtilis and the model plant Arabidopsis

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

How does invasive hybridization affect threatened native species?

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Our scientists working with laboratory animals undergo training on animal experiments. In this training, researchers learn how to handle laboratory animals responsibly. Read more about the requirements we set for researchers working with laboratory animals.

The single cell group (SCG) is part of the Metabolomics & Analytics Centre Our research is centered around developing innovating analytical methods tailored for small-volume, or single cell analysis to enable metabolomics-driven systems biology in personalized health strategies. We are always on…

Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

Day-to-day activities are important in the development of social identities, the establishment of social standing, and the communal understanding of societal rules. This perspective is broadly referred to as practice theory and relates to the power of an overarching social structure and the individual…

Research into the evolutionary backgrounds of our diets can help us make the right choices in diet, health and lifestyle.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.