This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

How do Humanitarian Response Organizations (HROs) and Virtual & Technical Communities (V&TCs) collaboratively govern disaster sensemaking processes, and what challenges shape the effectiveness of these collaborations between 2010 and 2016?

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

On Wednesday 14 May 2025 Remzi Çakırlar successfully defended a doctoral thesis and graduated.

The urban graveyard presents several studies in which the results of older archaeological and osteoarchaeological research are compared to more recent excavation data from several Dutch, Belgian and Danish cities and towns.

On Wednesday 11 June 2025 Steffie van Gompel successfully defended a doctoral thesis and graduated.

On Tuesday 3 September 2024 Straton Papagianneas successfully defended a doctoral thesis and graduated.

On Friday 22 November 2024 Ye Jiang successfully defended a doctoral thesis and graduated.

This research aims to investigate how different social forces interact with hydropolitics in the Eastern Nile Basin and what are the constraints of engagement.

Understanding others’ emotional behavior is essential for navigating daily social life. But how is such an understanding achieved? The eye-tracking study by Yung-Ting Tsou and colleagues shows that children with hearing loss adopt a unique visual strategy that makes uses of explicit visual information…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

On 22 June, Anneke Koning defended the thesis 'Return to sender: a multi-method study of guardianship against transnational sexual exploitation of children'. The doctoral research was supervised by Joanne van der Leun, Masja van Meeteren and Johan van Wilsem.

Festival, Study trip Greek and Roman History 2026

Mapping sanitary infrastructure in large urban societies in the Low Countries, 1200–1900

What is students’ engagement in problem-based learning (PBL) and case-based learning (CBL) in teacher certification programs?

On Friday 16 May Juul Eijk successfully defended a doctoral thesis and graduated.

On Tuesday 14 January 2025 Milan Ismangil successfully defended a doctoral thesis and graduated.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

This collection of seventeen essays takes its inspiration from the scholarly achievements of the Dutch historian Jan Lucassen. They reflect a central theme in his research: the history of labor.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

This project aims to investigate the underlying (neurocognitive) linguistic processes of ellipsis resolution, particularly gapping.