1,852 search results for “chemical weapons” in the Public website
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Thermostable Nanodiscs for the development of novel biopharmaceuticals
Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…
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Reactivity on interstellar ice analogues
The
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Quantum Delta NL research programme
Quantum Delta NL, a research programme in which Leiden University participates, has been awarded 615 million euros from the National Growth Fund to help develop the Netherlands into a top player in quantum technology.
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Oxidation catalysis on Pt and Au: complexity of simple chemistry
Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Pride and Prejudice: Moral Languages in Scholarly Codes of Conduct, 1900-2000
If idioms employed in codes of conduct could be as idiosyncratic as examples suggest, then to what extent did early modern language of vice, too, persist in this genre?
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Teaching
Research training projects in the MCBIM group - Bachelor and master students of all chemistry related studies are more than welcome to take part in our research activities. We have various research projects, all in one way or another involving transition metal ions. Daily supervision in the laboratory…
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Underground alarms: volatile-mediated recruitment of beneficial soil bacteria by plants under biotic stress
Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.
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The Fate of Anatomical Collections
The changing status of anatomical collections from the early modern period to date.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Microglial lipid metabolism: a delicate balance
Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
Source: J Cheminform, Volume 7, Issue 1 (2015)
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What is the effect of long-term exposure to engineered nanomaterials (ENMS)?
Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Introduction
Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…
- Research projects
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Firearms incidents in the EU tracked real-time
Leiden criminologists have co-developed an artificial intelligence technology that tracks firearms incidents by scanning over 350 news sources.
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First comprehensive study on gun violence in Europe identifies alarming trends
The steady decline in lethal gun violence in the EU came to halt in 2012 and some countries, such as Sweden, have even noticed an increase since then. An arms race among drug criminals and an increase in the availability of illegal firearms could lead to more criminal and gun violence. This is one of…
- Volume 12 (2017)
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A synthetic vaccine against meningococcus
Leiden chemists recreated the bacterial capsule of meningococcus in the lab. With a few modifications, these capsules can serve as an extra safe and effective vaccine against these notorious bacteria, which can cause, for example, meningitis. PhD candidate Jacopo Enotarpi and his team published the…
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Rob BosmanFaculty of Science
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Sebastian GeibelFaculty of Science
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Sean McKennaFaculty of Science
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Jingming Liu
Faculty of Science
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Rico SingerFaculty of Science
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Amit CherianFaculty of Science
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Anne WentinkFaculty of Science
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Annemarieke PostmusFaculty of Science
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Athanasios Patsos
Faculty of Science
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Monika TimmerFaculty of Science
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Arina Belov
Faculty of Science
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Helen Koendjbiharie
Faculty of Science
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Dane Marijan
Faculty of Science
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Mirjam Huizenga
Faculty of Science
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Xinyu DiFaculty of Science
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Thierry Shema
Faculty of Science
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Teun Sweere
Faculty of Science
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Ritu Ghanghas
Faculty of Science
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Floor StevensFaculty of Science
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Zoë Vogelaar
Faculty of Science
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Brecht EllenbroekFaculty of Science
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Jana VolaricFaculty of Science
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Liesbeth van der VeldenFaculty of Science