Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.

Ebru Alazi ‘hacked’ an enzyme-producing system in the fungus Aspergillus niger in order to produce renewable energy more easily. She manipulated the fungus, making it produce more pectinases: enzymes mainly used in the food industry and in the production of renewable energy, such as biofuels. Promotion…

Previous research has shown that extreme shyness is hereditary, but because shyness is such a broad concept it is difficult to identify specific genes. Anita Harrewijn has discovered particular brain measurements that can help. PhD defence 18 January.

Three research projects with researchers from Leiden University have received a Dutch Research Council Open Competition Science-M grant. This is for innovative, high-quality fundamental research within the science domain.

Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…

The idea that modern humans displaced Neanderthals because they were better protected against toxic smoke components is now under fire. An earlier study that put forward this suggestion has now been refuted by genetic research by scientists from Leiden and Wageningen. This new research was published…

The way DNA folds, largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in Biophysical Journal.

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

Lecture

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.

Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…

This project on the role of FoxPs in vocal perception and production learning is part of nine PhD-positions funded by the NWO Gravitation Programme which was granted to the Dutch Research Consortium 'Language in Interaction'

An evolutionary 'trap' that has haunted crested and marbled newts for 25 million years: Leiden researchers have uncovered a mysterious DNA error that should not be able to arise – yet persists all the same. How is that possible? PhD candidate James France found new clues.

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

SuperCode: Sustainability PER AI-driven CO-DEsign

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

Physics and Engineering Approaches to Biomedicine and Pharmacology

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

An overview of awards and prizes granted to our staff and students in 2022, as well as special appointments at Leiden University and other institutions.

A full overview of MacBio PhD Theses.

The master’s programme Statistics & Data Science provides students with a thorough introduction to the general philosophy and methodology of statistical modelling and data analysis. The programme has two specialisations: Data Science and Statistical Science.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

docARTES is a doctoral programme for performers and composers. It offers a unique environment for critical reflection on musical practice.

Dr. Kirsten Leiss and Prof. Peter Klinkhamer received 900.000 euro’s from “Stichting Toegepaste Wetenschappen (STW)” and the company “Rijk Zwaan” to develop plants that are resistant to thrips, a major agricultural pest all over the world.

How do our cells keep DNA stored away? To find out, biochemist Remus Dame received a 3 million euro Science-Groot grant. Leiden University will share the grant with TU Delft, VU Amsterdam and the Hubrecht Institute.

Leiden researchers, Professor Remko Offringa and co-applicants Salma Balazadeh and Frederic Lens received an NWO-XL grant (2.5 million euros). Together with researchers in Wageningen and Groningen, they will study the genetic and environmental drivers of woodiness. From plant to molecule, the groups…

PhD candidate Sibel Bahtiri is one of the new Faces of Science. In videos and blogs, she will show what life is like as a young researcher.

Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make software faster and greener, improve cancer detection and reduce anxiety by manipulating the biological…

'Dialogues Between Artistic Research and Science and Technology Studies', edited by Henk Borgdorff, Peter Peters and Trevor Pinch, will be published by Routledge on November 18

PhD defence

PhD defence

PhD defence

In a festive and intimate award ceremony, plant scientist Omid Karami received the first edition of the Krijn Rietveld Memorial Innovation Award out of the hands of Wim Klop, Director of the Biotechnology Center at DSM. Several speakers spoke about Krijn Rietveld and why Karami deserves the prize that…

The Netherlands Organisation for Scientific Research (NWO) has awarded Veni funding to seventeen researchers who recently obtained their PhD. This award offers promising young scientists the opportunity to develop their own ideas over a period of three years.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…