The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Mechanisms fro drug resistance

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: A.P.IJzerman Co-promotor: A. Bender

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

During the course of drug discovery translational steps are made.

Coral reefs throughout the world are under threat. After studying the reefs in Malaysia, Zarinah Waheed concluded that there is room for improvement in coral reef conservation. PhD defence 22 November.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Vera van Noort, professor in Computational Systems Biology at the KU Leuven (Belgium), is appointed holder of the rotating chair “Van der Klaauw Professor” for the year 2015-2016 at the Institute of Biology. Holders of the chair bring inspiring research and teaching in theoretical biology to the University.…

PhD defence

On December 4th, Flor Rhebergen received the 2015 Unilever Research prize for his study achievements at the IBL for his outstanding work in the field of Evolutionary Biology. Flor Rhebergen received the “Ovum” sculpture and was awarded €2.500.

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

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PhD defence

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

The Biological- and Soft-Matter Physics Master specialisation is one of the two programmes Leiden offers in experimental Physics. The programme can to a high degree be tailored to individual needs and interests.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

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Education & outreach

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

PhD defence