“Is it possible to restore antibiotic sensitivity in resistant bacteria?” Dr. Tingjie Guo wondered. “Watch me and learn”, phage responded. Dr. Tingjie Guo received an open competition XS domain ENW grant from the Dutch Research Council (NWO) to investigate the evolutionary trade-off of antimicrobial…

About one and a half million people worldwide die each year from tuberculosis. For thirty years, therapy with antibiotics has been the same, while it takes far too long and can lead to resistant pathogens. Leiden researchers from four institutes are now joining forces to develop more effective and efficient…

Four researchers from Leiden University have been awarded NWO Open Competition grants in the Science domain. This is for research into subjects such as immune cells in tumours, antibiotic resistance and magnetic semiconductors.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Tuberculosis bacteria survive by hiding in our immune cells. In her PhD research, biologist Salomé Muñoz Sánchez explores how boosting the body’s own defenses might outsmart this deadly pathogen. Her work reveals two key proteins that help immune cells destroy the bacteria.

Transferring poo from healthy donors to the intestines of chronically ill people has beneficial effects on these recipients’ gut bacteria, also in the longer term. This is the conclusion of research by the Leiden University Medical Center (LUMC) and the Netherlands Donor Feces Bank (NDFB).

In Sci-Fi comic book Resist NOW!, wondrous adventures will illustrate possibilities to combat antimicrobial resistance. But the comic book will only be produced if enough money is raised to make the project into reality.

Effectively treating a severe case of pneumonia is often challenging. Identifying the pathogen behind it can be difficult. PhD candidate Ilona den Hartog tried something new: ‘We searched for answers in substances our own body produces.’ PhD defence on 17 September.

An impressive 12 researchers from Leiden University have been awarded an 800,000-euro grant by the Dutch Research Council (NWO). This will enable them to develop their own line of research over the next five years.

The fact that corona has created a wave of creativity is evident when walking around in the lab of pharmacologist Coen van Hasselt from the LACDR. Suddenly there were far fewer master's students permitted in the lab for their research. So Van Hasselt came up with smart solutions to enable lab work to…

Four Leiden researchers have been awarded Proof of Concept grants by the ERC. These grants, each worth 150,000 euros, help researchers translate the findings of previous ERC projects into innovative practical applications.

Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…

Biopharmaceutical sciences master's student Nicole ter Laak has won the KNMP Studentenprijs 2023. She wins the prize for her research project on dosing guidelines of antibiotics in newborn babies with a very low birth weight for gestational age.

Research to experiment with bacteria that grow like plants has been granted the NWO XS grant. These bacteria use light and carbon dioxide to grow, and will be designed especially for use in the biotechnological field. Tijn Delzenne and his supervisor Dennis Claessen can spend 50.000 euros on the exp…

Our university labs are bursting with cutting-edge research, but how do you commercialise these inventions and discoveries or translate them into outcomes that benefit society? Professor of biological chemistry Nathaniel Martin started a spin-off company with his team. ‘When it comes to valorisation…

Thanks to a clever research method, progress is being made in the quest for better tuberculosis medications. Within an American consortium that received a 30 million dollars grant, Leiden researcher Rob van Wijk plays a significant role. ‘The next breakthrough in tuberculosis research will come much…

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…

Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…

Rob van Wijk (LACDR, Leiden University) and Robin van den Biggelaar (LUCID, LUMC) have been awarded a €10,000 euro KIEM grant from Leiden University to start an interdisciplinary collaboration to investigate the potential of AMPK activation as an adjunctive therapy to enhance tuberculosis treatment.

From medicines from snake venom to supercrops and the origin of words. Thirteen researchers from Leiden University will receive Open Competition XS grants from the Dutch Research Council (NWO).

LUNHA strives to redefine global health by prioritizing justice, fairness, and inclusion in Africa. Through collaboration with diverse stakeholders, LUNHA aims to reshape global health research and foster a broader engagement with social sciences and humanities.

Nicole ter Laak (Master student Biopharmaceutical sciences) has won the third price of the “Dr Saal van Zwanenberg research price”. The award ceremony is on 14 November.

On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.

Paco Barona Gomez is the newest associate professor at the Institute of Biology Leiden (IBL). The Mexican researcher is fascinated by the evolution of natural products: compounds made by microbes, but also plants and animals. ‘It’s like we investigate chemical dark matter.’

National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…

Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…

How can we best treat infectious diseases in people with obesity? Hospital pharmacist and PhD researcher Koen van Rhee studied how obesity affects blood levels of two commonly used medicines. He also developed a method for pharmaceutical companies to test new drugs on this patient group.

Op zaterdag 3 juni vindt de Museumnacht Leiden plaats. Ook dit jaar zijn Leidse wetenschappers en studenten onderdeel van de programmering.

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

2,240 plant extracts from 1,299 different plant species of Dutch origin. That’s the collection of the Dutch Extract Library, which has recently been transferred to the Institute of Biology Leiden. To plant biologist and contact person for this library Pingtao Ding this is a true treasury. ‘To bring…

Leiden PhD candidate Jo-Anne Verschoor discovered that nearly twenty percent of the bacterial strains she studied could degrade plastic, though they needed some encouragement to do so. ‘Bacteria are just like people,’ says Verschoor. Her research was published in the journal Communications Biology,…

Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…

From pipetting in the lab to shining in front of the camera at a global student event. With 8.000 viewers watching the livestream, Marjolein Crooijmans presented the iGEM Giant Jamboree in Paris.

A bacterium hiding from the immune system and picking up bits of DNA from its environment. The result: gaining new traits, such as better protection against antibiotics. Fortunately, we have not found such a damning scenario yet. However, PhD student Renée Kapteijn did find the first clues, which…

The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.

Violette Defourt came to Leiden for her master’s just before Covid hit. Four years later, she is leading her own biotech company, which aims to radically speed up diagnostics.

It’s about much more than learning how to write a readable piece or give a presentation that doesn’t send the audience to sleep. The intensive Science Communication Summer School gives young scientists the chance to really make contact with the public.

Greenhouse gas emissions related to pharmaceutical consumption increased by 77 percent over the past 24 years, according to a Leiden University study published in The Lancet Planetary Health. Moreover, efficiency gains have stalled since 2008. ‘Our best option is reducing consumption and minimising…

The new institute manager of the IBL studied biology for six months, but went in a completely different direction: development cooperation and the financial sector. Three decades later, Resi Janssen is making a radical career switch. Or isn’t she? 'In ten years’ time I want IBL to be in a new, sustainable…

A true shower of awards for students from the Faculty of Science during the annual KHMW Young Talent Awards ceremony. On Monday, 25 November, no less than nine first-year students received a prize for the best academic results in their first year. In addition, there were graduation prizes for master’s…

Elephant toothpaste, a trip among the stars or a lecture on mathematical juggling: on Sunday 8 October 2023, the Faculty of Science opened its doors for the third edition of the Leiden Science Family Day. A programme jam-packed with workshops, demonstrations, lectures and peeks behind the scenes for…

Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.

Assistant professor Joost Willemse firmly believes that as a teacher, you’re never done learning. ‘Students ask questions about things you’ve never thought of yourself. Ultimately, that makes you better at your job.’ That’s why he always encourages his students to ask questions. And it’s appreciated:…

What determines healthy behavior and how do you promote healthy choices and routines? These are a few questions currently being addressed by Marieke Adriaanse, recently appointed Professor of Behavioral Intervention in Population Health Management at the Leiden University Medical Center (LUMC).