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2,015 search results for “binding study advies bsa” in the Public website

• Interactions from lipid membrane deformations Research output

  Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

• Minerva in her Study Dossier: Rembrandt and Leiden University

  Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…

• 
  Christopher Green University lecturer

  Faculty of Humanities

• Come and visit us!

  As a university, we offer you the best education you can get. Professors, tutors and lecturers are ready to teach and guide you. But we do more than that. Of course, studying is your own responsibility, but we are happy to help if you need support. You decide what and when; online or on campus. These…

• A chemical biology approach for targeting of ligand-drug conjugates Research output

  Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

• FragmEndoscopy: Medieval fragments in early modern book spines Research project

  During the early modern period, many medieval manuscripts were cut up into strips of parchment which were reused to reinforce the bindings of newly printed books. Until recently, these reused pieces of medieval manuscripts only came to light when the early modern book binding was damaged and/or subjected…

• Antibiotic Discovery: From mechanistic studies to target ID Research output

  The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

• About NIMAR The Netherlands Institute Morocco

  The institute is funded by the Ministries of Education, Culture and Science and of Foreign Affairs and by Leiden University. To safeguard the institute’s independence and interests in Morocco, it is part of the Netherlands Embassy in Rabat under Moroccan law. The institute performs its tasks under the…

• 
  Elizabeth (Liesbeth) de Lange Professor

  Faculty of Science

• About the programme Science for Sustainable Societies (BSc)

  Science for Sustainable Societies offers an exciting combination of theory and practice. While analysing and examining relevant topics from both the natural and the social sciences domains, you will also gain lots of hands-on experience. Interactive learning and working together in a team are important…

• 
  Nico Kaptein Professor Emeritus

  Faculty of Humanities

• 
  Peter Verhagen Guest

  Faculty of Humanities

• 
  Ab de Jong Professor

  Faculty of Humanities

• It's about time Research output

  This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

• LED3 Drug Discovery Case Studies Leiden Early Drug Discovery & Development

  To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

• 
  Boudewijn Walraven Professor emeritus

  Faculty of Humanities

• 
  Xiao Luo PhD candidate

  Faculty of Humanities

• 
  Haneen Omari University lecturer

  Faculty of Humanities

• 
  Maghiel van Crevel Professor

  Faculty of Humanities

• synthesis and application of paramagnetic probes for protein structure studies Research output

  The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

• Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists Research output

  Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

• 
  Henk Schulte Nordholt Professor emeritus

  Faculty of Humanities

• 
  Shirley Alexander PhD candidate / guest

  Faculty of Humanities

• 
  Francesca Rosati PhD candidate

  Faculty of Humanities

• 
  Geoffrey Cain PhD candidate

  Faculty of Humanities

• 
  Steven Hagers PhD candidate

  Faculty of Humanities

• 
  Edegar Da Conceição Savio

  Faculty of Humanities

• 
  Crewe Williams PhD candidate

  Faculty of Humanities

• 
  Amirardalan Emami

  Faculty of Humanities

• 
  Xiong Xiong PhD candidate

  Faculty of Humanities

• Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2) Research output

  Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

• More effective blocking of CCR2 receptor Leiden Early Drug Discovery & Development

  The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

• 
  Caroline Fernandes Caromano Researcher

  Faculty of Humanities

• Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors Research output

  Promotor: A.P. IJzerman

• Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors Research output

  Promotor: A.P. IJzerman

• Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease Research project

  How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

• Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci Research output

  Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

• 
  Marat Markert Lecturer

  Faculty of Humanities

• 
  Judith Frishman Professor emeritus

  Faculty of Humanities

• 
  Arie van der Kooij Professor emeritus

  Faculty of Humanities

• Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines Research output

  Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

• Bachelor Q&A (English) Leiden Institute of Advanced Computer Science (LIACS)

  On this page you can find answers to frequently asked questions.

• 
  Berthe Jansen University lecturer

  Faculty of Humanities

• Allosteric Modulation Research project

  Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

• 
  Paula Esteves dos Santos Jordao
• 
  Kiyan Foroutan PhD Candidate

  Faculty of Humanities

• 
  Hélène Nut External PhD candidate

  Faculty of Humanities

• 
  Sarah Holma

  Faculty of Humanities

• 
  Shuqi Jia PhD candidate

  Faculty of Humanities

• 
  Irene Hadiprayitno University Lecturer International Studies

  Faculty of Humanities