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2,101 search results for “binding study advies bsa” in the Public website

• allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action Research output

  Source: Mediators Inflamm (2014)

• Kinetic profiling of positive allosteric modulators of the mGlu2 receptor Research project

  Supervisor: Maarten Doornbos

• Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor Research project

  Supervisor: Lizi Xia

• 
  Christian Henderson University Lecturer International Relations / Modern Middle East Studies

  Faculty of Humanities

• 
  Jelle Bruning University Lecturer Middle Eastern Studies / Arabic

  Faculty of Humanities

• 
  Maria Riep PhD candidate

  Faculty of Archaeology

• From every angle: novel insights into CC chemokine receptor 2 pharmacology Research output

  The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

• Synthetic carbohydrate ligands for immune receptors Research output

  One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

• 
  Yujing Tan Lecturer

  Faculty of Humanities

• Supercritical carbon dioxide spray drying for the production of stable dried protein formulations Research output

  Promotor: W. Jiskoot, Co-promotor: H.A. Every

• 
  Nathal Dessing University Lecturer Anthropology of Religion

  Faculty of Humanities

• 
  Daný van Dam University Lecturer

  Faculty of Humanities

• 
  Mubarika Nugraheni PhD Candidate

  Faculty of Humanities

• 
  Shahab Daneshvar PhD candidate

  Faculty of Humanities

• 
  Guita Winkel Guest

  Faculty of Humanities

• 
  Erik-jan Zurcher Professor emeritus

  Faculty of Humanities

• 
  David Henley Professor

  Faculty of Humanities

• Author, Reader, Book: Medieval Authorship in Theory and Practice Research output

  This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.

• 
  Deniz Tat University Lecturer Turkish

  Faculty of Humanities

• 
  Elpine de Boer University Lecturer Psychology of Religion

  Faculty of Humanities

• Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates Research output

  We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

• Intracellular allosteric modulators for human CC chemokine receptors Research project

  Supervisor: Natalia Ortiz Zacarías

• 
  Mahmood Yenkimaleki Guest researcher

  Faculty of Humanities

• 
  Edmund Amann Professor

  Faculty of Humanities

• 
  Michael Herzfeld

  Faculty of Social and Behavioural Sciences

• 
  Tim Wuisman Tutor Bachelor Security Studies

  Faculty of Governance and Global Affairs

• 
  Léon Buskens Director NIMAR

  Faculty of Humanities

• Programme structure International Relations and Organisations (BSc)

  Studying International Relations and Organisations (IRO) you will address transboundary issues from a social sciences point of view. It is an international 3-year programme with a strong focus on current global affairs.

• Allosterism Cell Systems and Drug Safety

  The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

• Computational Drug Discovery

  Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

• Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands Research project

  Supervisor: Andrea Martella

• The synthesis of mannose-derived bioconjugates and enzyme inhibitors Research output

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

• Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides Research output

  The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

• Enzyme-substrate interactions in the processive enzyme xylanase Research output

  The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

• 
  Ali Shobeiri Assistant Professor

  Faculty of Humanities

• Focus on kinetics for better drug development News - 4 April 2017

  Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

• 
  Weishuo Li PhD candidate

  Faculty of Archaeology

• ‘Take medicine target saturation into account’ News - 25 January 2019

  Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

• 
  Jonathan Stökl University Lecturer

  Faculty of Humanities

• 
  Alireza Asghari
• 
  Onur Ada PhD candidate

  Faculty of Humanities

• 
  Ugur Derin PhD candidate

  Faculty of Humanities

• Career prospects School Psychology (MSc)

  A master in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

• About Institute for Philosophy

  Learn about the Institute’s mission, structure and academic community within Leiden University’s Faculty of Humanities.

• Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors Research project

  Supervisor: Xue Yang

• Molecular Pharmacology

  In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

• Research projects Predictive Pharmacology

  An overview of research projects at the Predictive Pharmacology group.

• Better ligands for G Protein-Coupled Receptors Research project

  The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

• Water related adsorbates on stepped platinum surfaces Research output

  Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

• Membrane Interactions Huber Lab

  Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…